Biology Seminar: R. Scott Stephens, M.D.
"Kinase-Mediated Regulation of Lung Endothelial Antioxidant Function"
Dr. R. Scott Stephens, M.D., is an assistant professor of medicine in the Division of Pulmonary and Critical Care Medicine at The Johns Hopkins University. Dr. Stephens’ research interest is in acute lung injury, a common and often lethal condition. Specifically, he has focused on the pulmonary endothelium-- the cell layer which lines the blood vessels in the lungs --and the regulation of endothelial antioxidants and endothelial permeability via protein kinase signaling. Using primary isolated mouse lung endothelial cells, the isolated perfused mouse lung, knock-out mice and intact animal models, he has shown that activation of Protein Kinase G by cGMP increases levels of antioxidants in pulmonary endothelium, leading to increased resistance to oxidant-mediated acute lung injury. Most recently, he has described a novel interaction between PKG and the c-Abl tyrosine kinase and has found that inhibition of c-Abl also attenuates oxidant-induced lung injury. His long-term goal is to develop new approaches to treating patients with acute lung injury and improve the outcomes of patients with this condition.