Introduction

Back

Neuroscience

Neuroscience Advisory Committee: Professors Baird, Cohen, Kim, Trapani, Turgeon (Chair), Visiting Assistant Professor Roche.

Affiliated Faculty: Professors Clotfelter and Goutte.

The Neuroscience major consists of science courses in Biology, Chemistry, Mathematics, Physics, and Psychology, plus senior comprehensives, which includes attending neuroscience seminars and a comprehensive examination. Neuroscience majors may also choose to do a senior honors research project in the laboratory of a Neuroscience faculty member or affiliated Biology faculty member (and in some cases a faculty member from UMass-Amherst). Neuroscience majors must preregister for all courses that they will use to satisfy requirements for the major, rather than assume they will be guaranteed entry into a course during the add/drop period (e.g., you must preregister for NEUR 301 and/or NEUR 351). Courses in which a student has not received a letter grade better than "D" are not counted towards the Neuroscience major.

To receive Advanced Placement (AP) in a neuroscience course, you must have fulfilled the following requirements:

Chemistry: with a Chemistry AP score of 4 or 5, follow the recommendation made during orientation (many students with AP credit still take CHEM 151).Math: you may place out MATH 111 with a score of 4 or 5 on the AB exam or a 3 on the BC exam. In this case, you still need to satisfy the Physics/Mathematics requirement with a higher-level.Biology: you may place out of BIOL 191 with a score of 5 on the Biology AP exam. In this case you must substitute BIOL 251 or BIOL 291 for BIOL 191.

Neuroscience majors must complete the following requirements:

(1) General science requirements:

Chemistry: All of the following:

CHEM 151 (or 155)CHEM 161CHEM 221 (most majors also take CHEM 231)

Biology:

BIOL 191Note: BIOL 181 is optional for Neuroscience, but should be considered by students in their first year that are considering majoring in Biology or Neuroscience but haven't decided between them yet.

Statistics: One of the following:

STAT 111 (formerly MATH 130) orMATH/STAT 135 orSTAT 230 (formerly MATH 230) orBIOL 210 orPSYC 122

Physics/Mathematics: At least two of the following courses:

PHYS 116, 117, 123, 124MATH 111, 121, 211If you have Advanced Placement in any of these subjects, take more advanced courses.MATH 111 or Advanced Placement (at least 4 on AB or 3 on BC) is a prerequisite for CHEM 161 and PHYS 117.The Statistics requirement above is a separate requirement and does not count towards this Physics/Math requirement.

(2) Introduction to Neuroscience course:

Neuroscience Majors must take the following two courses:

NEUR 213: Neuroscience: Systems and Behavior (with lab)NEUR 214: Neurobiology (non lab)Note: The NEUR 213 course must be taken in the spring semester of your sophomore year. The NEUR 214 course may be taken in the fall of either sophomore or junior year but must be completed prior to the end of junior year.

(3) Upper-level Behavioral Neuroscience:

One of the following seminar courses:

NEUR 325 PsychopharmacologyNEUR 356 Neurophysiology of Motivation

(4) Upper-level Cellular/Molecular Neuroscience:

One of the following lab courses:

NEUR 301 Molecular Neurobiology with laboratoryNEUR 351 Neurophysiology with laboratory

(5) Upper-level Human Neuroscience:

Neuroscience Majors must take one of the following courses:

NEUR 361 Consciousness and the BrainNEUR 367 Human Neuroscience

(6) Upper-level Elective:

One additional upper-level elective from the following courses:

An additional behavioral neuroscience course from item (3) aboveAn additional molecular/cellular neuroscience course from item (4) aboveAn additional human neuroscience course from item (5) aboveNEUR 350 Neurophysiology (non-lab section of NEUR 351)NEUR 425 Systems NeuroscienceNEUR 450 Seminar in PhysiologyBIOL 221 Developmental Biology (w/ lab)BIOL 241 Genetic Analysis (w/ lab)BIOL 251 Molecular Genetics (w/ lab)BIOL 260 Animal PhysiologyBIOL 271 Microbiology (w/ lab)BIOL 281 Animal Behavior (w/ lab)BIOL 291 Cell Structure and Function (w/ lab)BIOL 331 Biochemistry (w/ lab)BIOL 381 Genome Biology (w/ lab)BIOL/NEUR 411 Seminar in Synapses: Synaptic Development and PlasticityPSYC 233 Cognitive PsychologyPSYC 234 MemoryPSYC 236 Psychology of AgingPSYC 357 History of Psychiatry

* On leave 2022-23.† On leave fall semester 2022-23. ‡ On leave spring semester 2022-23.

211 Cognitive Neuroscience

(Offered as PSYC 211 and NEUR 211) Historically, psychologists and neuroscientists have worked somewhat in parallel to one another. While psychologists have traditionally focused on how humans think, feel, and behave, neuroscientists have primarily focused exclusively on the workings of the brain. Cognitive neuroscience is a relatively new discipline that lies at the intersection of these fields and seeks to understand the neurobiological processes that underlie cognition. This course serves as a broad introduction to the field of cognitive neuroscience and will focus on a variety of questions, including the following: How does the brain obtain and process information about the environment via sight, taste, and touch? How does the brain support our capacity to learn and speak different languages? What happens to the brain when it is afflicted with neurological disorders such as Alzheimer’s, amnesia, schizophrenia, and autism? This course will provide students with a foundational understanding of modern cognitive neuroscience and the ways in which researchers examine the relationship between the mind and the brain.

Requisite: PSYC 100 or consent of the instructor. Limited to 40 students. Offered Fall 2022: Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2020, Fall 2020, Fall 2022, Fall 2023

213 Neuroscience: Systems and Behavior

(Offered as PSYC 213 and NEUR 213) This course will examine how brain function regulates a broad range of mental processes and behaviors. We will discuss how neurons work and how the brain obtains information about the environment (sensory systems), regulates an organism’s response to the environment (motor systems), controls basic functions necessary for survival such as eating, drinking, sex, and sleep, and mediates higher cognitive function such as memory and language. We will also consider the consequences of brain malfunction as manifested in various forms of disease and mental illness. Laboratories will include basic neuroanatomy and behavioral experiments. Three class hours and three hours of laboratory per week.

Requisite: BIOL 191 or PSYC 100 or consent of the instructor. Cannot be taken if PSYC 212 has been taken because of substantial overlap between the two courses. Limited to 36 students. Spring semester. Professor Baird.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2019, Spring 2024

214 Neurobiology

(Offered as BIOL 214 and NEUR 214) An introduction to the structure and function of the nervous system, this course explores the basic functions of neurons and synapses as well as neural mechanisms of sensation at molecular, cellular, circuit and system levels. Basic topics in neurobiology and neurophysiology will be covered with emphasis on neuroscience history and understanding how neuroscientists approach the study of the nervous system. Three class hours per week.

Requisite: BIOL 191. Limited to 45 students. Fall and Spring semester. Professors Kim and Roche.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

245 Systems Neuroscience

The course will survey behavioral neurobiological systems. Students will explore recent research findings in areas pertaining to the role of neural circuits in several behavioral processes including but not limited to echolocation, mating, prey location, flight control, spatial navigation, song development in birds, mineral appetites, social functions, aggression, and learning and memory mechanisms in several species. Through instructor supervision, discussion, group presentations, and peer review, each student develops a specific research project that results in a research proposal. The course will place significant emphasis on the development of writing skills. Key goals of the course are to prepare juniors for upper-level seminars and to provide an intensive literature-research and writing experience. This course will count as a Group A/List A elective course for the neuroscience major.

Limited to juniors and seniors who have taken NEUR 226 or NEUR 213/214 or consent of the instructor. Limited to 18 students. Fall semester. Professor Baird.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022

301 Molecular Neurobiology with Lab

(Offered as BIOL 301 and NEUR 301) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain and synapse development as well as neuronal death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will supplement the lectures and also emphasize current molecular techniques utilized in the study of the nervous system. Four classroom hours and three hours of laboratory per week.

While enrolled at the college, students may only take either BIOL/NEUR-301 or BIOL/NEUR-303.

Requisite: Bio 191. Bio/Neur 214 strongly suggested.

Limited to 18 students. Spring semester. Professor Roche.

2022-23: Not offered
Other years: Offered in Fall 2011, Fall 2014, Fall 2015, Fall 2016, Spring 2020, Spring 2021, Spring 2022, Fall 2023

303 Molecular Neurobiology: CURE

(Offered as BIOL 303 and NEUR 303) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain development, from neurogenesis, neurite growth, and synaptogenesis to cell death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will emphasize current molecular techniques utilized in the study of the nervous system. This course is a CURE, a Course-based Undergraduate Research Experience. Students will engage in scientific practice, make novel discoveries, participate in iterative work and collaborate with peers. The goal is to give students an authentic research experience in which they will acquire necessary skills for being a scientist. Four classroom hours and three hours of laboratory per week.

Requisite: BIOL 214 or BIOL 260. Limited to 18 students. Spring semester. Professor Kim.

2022-23: Offered in Spring 2023

317 Neurobiology of Appetite

Although the ingestive act per se is clear and simple, understanding the multifarious influences that are distilled into the decision at any given moment to eat, or not to eat, remains a ponderous challenge for scientists. The obesity epidemic of the last several decades continues to spread across the globe, leading to a rise in metabolic diseases and more pressing need than ever to understand the neurobiological controls of eating and body weight. Through a broad survey of neurobiological research literature, we will explore how various neurobiological systems and behavioral processes influence eating and body weight, including metabolism, neural mechanisms of hunger and satiety, metabolic disorders, dieting, pica, failure to thrive, starvation, taste preference and aversion, obesity, anxiety and depression, food taboos, and all eating disorders. Strong emphasis will be placed on biological mechanisms and controlled laboratory research with both human and animal subjects.

Limited to 20 students. Open to juniors and seniors. Fall semester. Prof. Baird.  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Fall 2023

325 Psychopharmacology

(Offered as PSYC 325 and NEUR 325) In this course we will examine the ways in which drugs act on the brain to alter behavior. We will review basic principles of brain function and mechanisms of drug action in the brain. We will discuss a variety of legal and illegal recreational drugs as well as the use of psychotherapeutic drugs to treat mental illness. Examples from the primary scientific literature will demonstrate the various methods used to investigate mechanisms of drug action, the biological and behavioral consequences of drug use, and the nature of efforts to prevent or treat drug abuse.

Requisite: PSYC 212/NEUR 213, or consent of the instructor. Limited to 18 students. Not open to five college students. Spring semester. Professor Turgeon.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Spring 2018, Spring 2019, Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

351 Neurophysiology with Lab

(Offered as BIOL 351 and NEUR 351) This laboratory course will provide a deeper understanding of the physiological properties of the nervous system. We will address the mechanisms underlying electrical activity in neurons, as well as examine the physiology of synapses; the transduction and integration of sensory information; the function of nerve circuits; the trophic and plastic properties of neurons; and the relationship between neuronal activity and behavior. Laboratories will apply electrophysiological methods to examine neuronal activity and will include experimental design as well as analysis and presentation of collected data. Throughout the course, we will focus on past and current neurophysiology research and how it contributes to the field of neuroscience. Three hours of laboratory work per week.

Requisites: BIOL 191 and CHEM 151; PHYS 117 or 124 is recommended. Limited to one lab section with 18 students. Open to juniors and seniors. Fall semester. Professor Trapani.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2012, Fall 2013, Fall 2016, Fall 2022

361 Consciousness and the Brain

(Offered as PSYC 361 and NEUR 361) Although curiosity about the nature of consciousness has animated the work of philosophers, artists and others, this course will approach the topic from a scientific perspective. How do electrochemical signals in our brain produce our experience of colors, sounds, tastes and our awareness of ourselves? We will read and discuss primary source scientific journal articles drawn from both psychology and neuroscience with a focus on questions including: What kinds of brain activity distinguish conscious from unconscious states? Can objects in the environment (e.g., advertisements) affect our behavior even if we are not consciously aware of those objects? Are there different types of consciousness? Is consciousness peculiar to human beings (does it require language?) or is consciousness experienced by other species, as well? Does science have the tools necessary to achieve a complete understanding of human consciousness? Overall, the goal of this course is to provide students with a thorough understanding of the current states of the scientific study of consciousness.

Requisite: PSYC 211, PSYC 212, PSYC 233, or PSYC/NEUR 213. Limited to 18 students. Offered Fall semester. Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2018, Fall 2019, Spring 2021, Fall 2022, Fall 2023

367 Human Neuroscience

(Offered as PSYC 367 and NEUR 367) This course will be an in-depth exploration of contemporary issues in the field of human neuroscience. Topics include a rigorous examination of the methods neuroscientists use to study the human brain, how the brain changes throughout the lifespan, the ways in which researchers have developed brain/machine interfaces, and the neural processes that support decision-making. For each topic, we will read several empirical articles and discuss them with an emphasis on experimental design, factors that may be confounding the data, and interpretation of the data. Assignments will include weekly response papers, an oral presentation, in-class debates, and a research proposal. Overall, the goal of this course is for students to gain an understanding of the cutting edge of human neuroscience research and to increase their ability to think like scientists.

Requisite: PSYC 211 or PSYC 212 or PSYC/NEUR 213 or consent of the instructor. Limited to 18 students. Offered spring semester. Professor Cohen.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2020, Spring 2021, Spring 2024

390 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2007, Fall 2008, Fall 2009, Fall 2010, Fall 2011, Fall 2022

391 Quantitative Imaging with Lab: From Molecules to Cells and Beyond

(Offered as BIOL 391, BCBP 391, and NEUR-391) Fluorescence imaging offers a window to understanding the structure and function of living cells at sub-cellular resolution. This laboratory and lecture course will focus on advanced quantitative fluorescence microscopy techniques used for imaging a range of biological model systems and functions ranging from single molecules to cells to tissues. Students will learn the fundamentals of optics and microscopy and gain hands-on experience with classical and emerging imaging technology including: confocal microscopy, deconvolution and super-resolution methods, and live-cell imaging. Fluorescent probes and genetically encoded biosensors will be discussed and used to study dynamic cellular processes. In addition, the class will explore a range of image processing and analysis workflows. Lectures dealing with the theory, mechanics, and application of fluorescent imaging methods will be intermingled with extended laboratory sessions in our new Amherst Biological Imaging Center.

Pre requisites : BIOL 191 and PHYS 117 and one of BIOL/BCBP291, BIOL221 or BIOL/NEUR 301, or with instructor permission.

There will be two 80-minute lectures and a weekly laboratory. Limited to 12 students. Fall semester. Professors Edwards and Kim  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Spring 2024

450 Seminar in Physiology: Classic Papers in Neurophysiology

(Offered as BIOL 450 and NEUR 450) Concentrating on reading and interpreting primary research, this course will focus on classic and soon-to-be classic neurophysiology papers. We will discuss the seminal experiments performed in the 1950s that led to our understanding of action potentials; experiments in the 1960s and 1970s that unlocked how synapses function; and more recent research that combines electrophysiology with optical methods and genetic techniques to investigate the role of many of the molecular components predicted by the work from the earlier decades. Assignments will include written reviews of literature as well as oral presentations.

Requisite: PHYS 117 or PHYS 124 and one of BIOL-214, BIOL 260, BIOL 350/351, or consent of the instructor. Limited to 18 students. Not open to first-year students. Spring Semester. Professor Trapani.

2022-23: Not offered
Other years: Offered in Spring 2013, Spring 2017, Spring 2019, Spring 2022, Spring 2024

490 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2013, Spring 2014, Fall 2014, Spring 2015, Fall 2015, Spring 2016, Fall 2016, Spring 2017, Fall 2017, Spring 2018, Fall 2018, Spring 2019, Fall 2019, Spring 2020, Fall 2020, Spring 2021, Fall 2021, Spring 2022, Fall 2022

498, 498D, 499, 499D Senior Departmental Honors

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research.

Fall semester. The Committee.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Fall 2017, Fall 2018, Fall 2019, Fall 2020, January 2021, Fall 2021, Fall 2022, Fall 2023
Department Website

About Amherst College

Back

Neuroscience

Neuroscience Advisory Committee: Professors Baird, Cohen, Kim, Trapani, Turgeon (Chair), Visiting Assistant Professor Roche.

Affiliated Faculty: Professors Clotfelter and Goutte.

The Neuroscience major consists of science courses in Biology, Chemistry, Mathematics, Physics, and Psychology, plus senior comprehensives, which includes attending neuroscience seminars and a comprehensive examination. Neuroscience majors may also choose to do a senior honors research project in the laboratory of a Neuroscience faculty member or affiliated Biology faculty member (and in some cases a faculty member from UMass-Amherst). Neuroscience majors must preregister for all courses that they will use to satisfy requirements for the major, rather than assume they will be guaranteed entry into a course during the add/drop period (e.g., you must preregister for NEUR 301 and/or NEUR 351). Courses in which a student has not received a letter grade better than "D" are not counted towards the Neuroscience major.

To receive Advanced Placement (AP) in a neuroscience course, you must have fulfilled the following requirements:

Chemistry: with a Chemistry AP score of 4 or 5, follow the recommendation made during orientation (many students with AP credit still take CHEM 151).Math: you may place out MATH 111 with a score of 4 or 5 on the AB exam or a 3 on the BC exam. In this case, you still need to satisfy the Physics/Mathematics requirement with a higher-level.Biology: you may place out of BIOL 191 with a score of 5 on the Biology AP exam. In this case you must substitute BIOL 251 or BIOL 291 for BIOL 191.

Neuroscience majors must complete the following requirements:

(1) General science requirements:

Chemistry: All of the following:

CHEM 151 (or 155)CHEM 161CHEM 221 (most majors also take CHEM 231)

Biology:

BIOL 191Note: BIOL 181 is optional for Neuroscience, but should be considered by students in their first year that are considering majoring in Biology or Neuroscience but haven't decided between them yet.

Statistics: One of the following:

STAT 111 (formerly MATH 130) orMATH/STAT 135 orSTAT 230 (formerly MATH 230) orBIOL 210 orPSYC 122

Physics/Mathematics: At least two of the following courses:

PHYS 116, 117, 123, 124MATH 111, 121, 211If you have Advanced Placement in any of these subjects, take more advanced courses.MATH 111 or Advanced Placement (at least 4 on AB or 3 on BC) is a prerequisite for CHEM 161 and PHYS 117.The Statistics requirement above is a separate requirement and does not count towards this Physics/Math requirement.

(2) Introduction to Neuroscience course:

Neuroscience Majors must take the following two courses:

NEUR 213: Neuroscience: Systems and Behavior (with lab)NEUR 214: Neurobiology (non lab)Note: The NEUR 213 course must be taken in the spring semester of your sophomore year. The NEUR 214 course may be taken in the fall of either sophomore or junior year but must be completed prior to the end of junior year.

(3) Upper-level Behavioral Neuroscience:

One of the following seminar courses:

NEUR 325 PsychopharmacologyNEUR 356 Neurophysiology of Motivation

(4) Upper-level Cellular/Molecular Neuroscience:

One of the following lab courses:

NEUR 301 Molecular Neurobiology with laboratoryNEUR 351 Neurophysiology with laboratory

(5) Upper-level Human Neuroscience:

Neuroscience Majors must take one of the following courses:

NEUR 361 Consciousness and the BrainNEUR 367 Human Neuroscience

(6) Upper-level Elective:

One additional upper-level elective from the following courses:

An additional behavioral neuroscience course from item (3) aboveAn additional molecular/cellular neuroscience course from item (4) aboveAn additional human neuroscience course from item (5) aboveNEUR 350 Neurophysiology (non-lab section of NEUR 351)NEUR 425 Systems NeuroscienceNEUR 450 Seminar in PhysiologyBIOL 221 Developmental Biology (w/ lab)BIOL 241 Genetic Analysis (w/ lab)BIOL 251 Molecular Genetics (w/ lab)BIOL 260 Animal PhysiologyBIOL 271 Microbiology (w/ lab)BIOL 281 Animal Behavior (w/ lab)BIOL 291 Cell Structure and Function (w/ lab)BIOL 331 Biochemistry (w/ lab)BIOL 381 Genome Biology (w/ lab)BIOL/NEUR 411 Seminar in Synapses: Synaptic Development and PlasticityPSYC 233 Cognitive PsychologyPSYC 234 MemoryPSYC 236 Psychology of AgingPSYC 357 History of Psychiatry

* On leave 2022-23.† On leave fall semester 2022-23. ‡ On leave spring semester 2022-23.

211 Cognitive Neuroscience

(Offered as PSYC 211 and NEUR 211) Historically, psychologists and neuroscientists have worked somewhat in parallel to one another. While psychologists have traditionally focused on how humans think, feel, and behave, neuroscientists have primarily focused exclusively on the workings of the brain. Cognitive neuroscience is a relatively new discipline that lies at the intersection of these fields and seeks to understand the neurobiological processes that underlie cognition. This course serves as a broad introduction to the field of cognitive neuroscience and will focus on a variety of questions, including the following: How does the brain obtain and process information about the environment via sight, taste, and touch? How does the brain support our capacity to learn and speak different languages? What happens to the brain when it is afflicted with neurological disorders such as Alzheimer’s, amnesia, schizophrenia, and autism? This course will provide students with a foundational understanding of modern cognitive neuroscience and the ways in which researchers examine the relationship between the mind and the brain.

Requisite: PSYC 100 or consent of the instructor. Limited to 40 students. Offered Fall 2022: Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2020, Fall 2020, Fall 2022, Fall 2023

213 Neuroscience: Systems and Behavior

(Offered as PSYC 213 and NEUR 213) This course will examine how brain function regulates a broad range of mental processes and behaviors. We will discuss how neurons work and how the brain obtains information about the environment (sensory systems), regulates an organism’s response to the environment (motor systems), controls basic functions necessary for survival such as eating, drinking, sex, and sleep, and mediates higher cognitive function such as memory and language. We will also consider the consequences of brain malfunction as manifested in various forms of disease and mental illness. Laboratories will include basic neuroanatomy and behavioral experiments. Three class hours and three hours of laboratory per week.

Requisite: BIOL 191 or PSYC 100 or consent of the instructor. Cannot be taken if PSYC 212 has been taken because of substantial overlap between the two courses. Limited to 36 students. Spring semester. Professor Baird.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2019, Spring 2024

214 Neurobiology

(Offered as BIOL 214 and NEUR 214) An introduction to the structure and function of the nervous system, this course explores the basic functions of neurons and synapses as well as neural mechanisms of sensation at molecular, cellular, circuit and system levels. Basic topics in neurobiology and neurophysiology will be covered with emphasis on neuroscience history and understanding how neuroscientists approach the study of the nervous system. Three class hours per week.

Requisite: BIOL 191. Limited to 45 students. Fall and Spring semester. Professors Kim and Roche.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

245 Systems Neuroscience

The course will survey behavioral neurobiological systems. Students will explore recent research findings in areas pertaining to the role of neural circuits in several behavioral processes including but not limited to echolocation, mating, prey location, flight control, spatial navigation, song development in birds, mineral appetites, social functions, aggression, and learning and memory mechanisms in several species. Through instructor supervision, discussion, group presentations, and peer review, each student develops a specific research project that results in a research proposal. The course will place significant emphasis on the development of writing skills. Key goals of the course are to prepare juniors for upper-level seminars and to provide an intensive literature-research and writing experience. This course will count as a Group A/List A elective course for the neuroscience major.

Limited to juniors and seniors who have taken NEUR 226 or NEUR 213/214 or consent of the instructor. Limited to 18 students. Fall semester. Professor Baird.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022

301 Molecular Neurobiology with Lab

(Offered as BIOL 301 and NEUR 301) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain and synapse development as well as neuronal death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will supplement the lectures and also emphasize current molecular techniques utilized in the study of the nervous system. Four classroom hours and three hours of laboratory per week.

While enrolled at the college, students may only take either BIOL/NEUR-301 or BIOL/NEUR-303.

Requisite: Bio 191. Bio/Neur 214 strongly suggested.

Limited to 18 students. Spring semester. Professor Roche.

2022-23: Not offered
Other years: Offered in Fall 2011, Fall 2014, Fall 2015, Fall 2016, Spring 2020, Spring 2021, Spring 2022, Fall 2023

303 Molecular Neurobiology: CURE

(Offered as BIOL 303 and NEUR 303) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain development, from neurogenesis, neurite growth, and synaptogenesis to cell death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will emphasize current molecular techniques utilized in the study of the nervous system. This course is a CURE, a Course-based Undergraduate Research Experience. Students will engage in scientific practice, make novel discoveries, participate in iterative work and collaborate with peers. The goal is to give students an authentic research experience in which they will acquire necessary skills for being a scientist. Four classroom hours and three hours of laboratory per week.

Requisite: BIOL 214 or BIOL 260. Limited to 18 students. Spring semester. Professor Kim.

2022-23: Offered in Spring 2023

317 Neurobiology of Appetite

Although the ingestive act per se is clear and simple, understanding the multifarious influences that are distilled into the decision at any given moment to eat, or not to eat, remains a ponderous challenge for scientists. The obesity epidemic of the last several decades continues to spread across the globe, leading to a rise in metabolic diseases and more pressing need than ever to understand the neurobiological controls of eating and body weight. Through a broad survey of neurobiological research literature, we will explore how various neurobiological systems and behavioral processes influence eating and body weight, including metabolism, neural mechanisms of hunger and satiety, metabolic disorders, dieting, pica, failure to thrive, starvation, taste preference and aversion, obesity, anxiety and depression, food taboos, and all eating disorders. Strong emphasis will be placed on biological mechanisms and controlled laboratory research with both human and animal subjects.

Limited to 20 students. Open to juniors and seniors. Fall semester. Prof. Baird.  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Fall 2023

325 Psychopharmacology

(Offered as PSYC 325 and NEUR 325) In this course we will examine the ways in which drugs act on the brain to alter behavior. We will review basic principles of brain function and mechanisms of drug action in the brain. We will discuss a variety of legal and illegal recreational drugs as well as the use of psychotherapeutic drugs to treat mental illness. Examples from the primary scientific literature will demonstrate the various methods used to investigate mechanisms of drug action, the biological and behavioral consequences of drug use, and the nature of efforts to prevent or treat drug abuse.

Requisite: PSYC 212/NEUR 213, or consent of the instructor. Limited to 18 students. Not open to five college students. Spring semester. Professor Turgeon.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Spring 2018, Spring 2019, Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

351 Neurophysiology with Lab

(Offered as BIOL 351 and NEUR 351) This laboratory course will provide a deeper understanding of the physiological properties of the nervous system. We will address the mechanisms underlying electrical activity in neurons, as well as examine the physiology of synapses; the transduction and integration of sensory information; the function of nerve circuits; the trophic and plastic properties of neurons; and the relationship between neuronal activity and behavior. Laboratories will apply electrophysiological methods to examine neuronal activity and will include experimental design as well as analysis and presentation of collected data. Throughout the course, we will focus on past and current neurophysiology research and how it contributes to the field of neuroscience. Three hours of laboratory work per week.

Requisites: BIOL 191 and CHEM 151; PHYS 117 or 124 is recommended. Limited to one lab section with 18 students. Open to juniors and seniors. Fall semester. Professor Trapani.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2012, Fall 2013, Fall 2016, Fall 2022

361 Consciousness and the Brain

(Offered as PSYC 361 and NEUR 361) Although curiosity about the nature of consciousness has animated the work of philosophers, artists and others, this course will approach the topic from a scientific perspective. How do electrochemical signals in our brain produce our experience of colors, sounds, tastes and our awareness of ourselves? We will read and discuss primary source scientific journal articles drawn from both psychology and neuroscience with a focus on questions including: What kinds of brain activity distinguish conscious from unconscious states? Can objects in the environment (e.g., advertisements) affect our behavior even if we are not consciously aware of those objects? Are there different types of consciousness? Is consciousness peculiar to human beings (does it require language?) or is consciousness experienced by other species, as well? Does science have the tools necessary to achieve a complete understanding of human consciousness? Overall, the goal of this course is to provide students with a thorough understanding of the current states of the scientific study of consciousness.

Requisite: PSYC 211, PSYC 212, PSYC 233, or PSYC/NEUR 213. Limited to 18 students. Offered Fall semester. Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2018, Fall 2019, Spring 2021, Fall 2022, Fall 2023

367 Human Neuroscience

(Offered as PSYC 367 and NEUR 367) This course will be an in-depth exploration of contemporary issues in the field of human neuroscience. Topics include a rigorous examination of the methods neuroscientists use to study the human brain, how the brain changes throughout the lifespan, the ways in which researchers have developed brain/machine interfaces, and the neural processes that support decision-making. For each topic, we will read several empirical articles and discuss them with an emphasis on experimental design, factors that may be confounding the data, and interpretation of the data. Assignments will include weekly response papers, an oral presentation, in-class debates, and a research proposal. Overall, the goal of this course is for students to gain an understanding of the cutting edge of human neuroscience research and to increase their ability to think like scientists.

Requisite: PSYC 211 or PSYC 212 or PSYC/NEUR 213 or consent of the instructor. Limited to 18 students. Offered spring semester. Professor Cohen.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2020, Spring 2021, Spring 2024

390 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2007, Fall 2008, Fall 2009, Fall 2010, Fall 2011, Fall 2022

391 Quantitative Imaging with Lab: From Molecules to Cells and Beyond

(Offered as BIOL 391, BCBP 391, and NEUR-391) Fluorescence imaging offers a window to understanding the structure and function of living cells at sub-cellular resolution. This laboratory and lecture course will focus on advanced quantitative fluorescence microscopy techniques used for imaging a range of biological model systems and functions ranging from single molecules to cells to tissues. Students will learn the fundamentals of optics and microscopy and gain hands-on experience with classical and emerging imaging technology including: confocal microscopy, deconvolution and super-resolution methods, and live-cell imaging. Fluorescent probes and genetically encoded biosensors will be discussed and used to study dynamic cellular processes. In addition, the class will explore a range of image processing and analysis workflows. Lectures dealing with the theory, mechanics, and application of fluorescent imaging methods will be intermingled with extended laboratory sessions in our new Amherst Biological Imaging Center.

Pre requisites : BIOL 191 and PHYS 117 and one of BIOL/BCBP291, BIOL221 or BIOL/NEUR 301, or with instructor permission.

There will be two 80-minute lectures and a weekly laboratory. Limited to 12 students. Fall semester. Professors Edwards and Kim  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Spring 2024

450 Seminar in Physiology: Classic Papers in Neurophysiology

(Offered as BIOL 450 and NEUR 450) Concentrating on reading and interpreting primary research, this course will focus on classic and soon-to-be classic neurophysiology papers. We will discuss the seminal experiments performed in the 1950s that led to our understanding of action potentials; experiments in the 1960s and 1970s that unlocked how synapses function; and more recent research that combines electrophysiology with optical methods and genetic techniques to investigate the role of many of the molecular components predicted by the work from the earlier decades. Assignments will include written reviews of literature as well as oral presentations.

Requisite: PHYS 117 or PHYS 124 and one of BIOL-214, BIOL 260, BIOL 350/351, or consent of the instructor. Limited to 18 students. Not open to first-year students. Spring Semester. Professor Trapani.

2022-23: Not offered
Other years: Offered in Spring 2013, Spring 2017, Spring 2019, Spring 2022, Spring 2024

490 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2013, Spring 2014, Fall 2014, Spring 2015, Fall 2015, Spring 2016, Fall 2016, Spring 2017, Fall 2017, Spring 2018, Fall 2018, Spring 2019, Fall 2019, Spring 2020, Fall 2020, Spring 2021, Fall 2021, Spring 2022, Fall 2022

498, 498D, 499, 499D Senior Departmental Honors

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research.

Fall semester. The Committee.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Fall 2017, Fall 2018, Fall 2019, Fall 2020, January 2021, Fall 2021, Fall 2022, Fall 2023
Department Website

Admission & Financial Aid

Back

Neuroscience

Neuroscience Advisory Committee: Professors Baird, Cohen, Kim, Trapani, Turgeon (Chair), Visiting Assistant Professor Roche.

Affiliated Faculty: Professors Clotfelter and Goutte.

The Neuroscience major consists of science courses in Biology, Chemistry, Mathematics, Physics, and Psychology, plus senior comprehensives, which includes attending neuroscience seminars and a comprehensive examination. Neuroscience majors may also choose to do a senior honors research project in the laboratory of a Neuroscience faculty member or affiliated Biology faculty member (and in some cases a faculty member from UMass-Amherst). Neuroscience majors must preregister for all courses that they will use to satisfy requirements for the major, rather than assume they will be guaranteed entry into a course during the add/drop period (e.g., you must preregister for NEUR 301 and/or NEUR 351). Courses in which a student has not received a letter grade better than "D" are not counted towards the Neuroscience major.

To receive Advanced Placement (AP) in a neuroscience course, you must have fulfilled the following requirements:

Chemistry: with a Chemistry AP score of 4 or 5, follow the recommendation made during orientation (many students with AP credit still take CHEM 151).Math: you may place out MATH 111 with a score of 4 or 5 on the AB exam or a 3 on the BC exam. In this case, you still need to satisfy the Physics/Mathematics requirement with a higher-level.Biology: you may place out of BIOL 191 with a score of 5 on the Biology AP exam. In this case you must substitute BIOL 251 or BIOL 291 for BIOL 191.

Neuroscience majors must complete the following requirements:

(1) General science requirements:

Chemistry: All of the following:

CHEM 151 (or 155)CHEM 161CHEM 221 (most majors also take CHEM 231)

Biology:

BIOL 191Note: BIOL 181 is optional for Neuroscience, but should be considered by students in their first year that are considering majoring in Biology or Neuroscience but haven't decided between them yet.

Statistics: One of the following:

STAT 111 (formerly MATH 130) orMATH/STAT 135 orSTAT 230 (formerly MATH 230) orBIOL 210 orPSYC 122

Physics/Mathematics: At least two of the following courses:

PHYS 116, 117, 123, 124MATH 111, 121, 211If you have Advanced Placement in any of these subjects, take more advanced courses.MATH 111 or Advanced Placement (at least 4 on AB or 3 on BC) is a prerequisite for CHEM 161 and PHYS 117.The Statistics requirement above is a separate requirement and does not count towards this Physics/Math requirement.

(2) Introduction to Neuroscience course:

Neuroscience Majors must take the following two courses:

NEUR 213: Neuroscience: Systems and Behavior (with lab)NEUR 214: Neurobiology (non lab)Note: The NEUR 213 course must be taken in the spring semester of your sophomore year. The NEUR 214 course may be taken in the fall of either sophomore or junior year but must be completed prior to the end of junior year.

(3) Upper-level Behavioral Neuroscience:

One of the following seminar courses:

NEUR 325 PsychopharmacologyNEUR 356 Neurophysiology of Motivation

(4) Upper-level Cellular/Molecular Neuroscience:

One of the following lab courses:

NEUR 301 Molecular Neurobiology with laboratoryNEUR 351 Neurophysiology with laboratory

(5) Upper-level Human Neuroscience:

Neuroscience Majors must take one of the following courses:

NEUR 361 Consciousness and the BrainNEUR 367 Human Neuroscience

(6) Upper-level Elective:

One additional upper-level elective from the following courses:

An additional behavioral neuroscience course from item (3) aboveAn additional molecular/cellular neuroscience course from item (4) aboveAn additional human neuroscience course from item (5) aboveNEUR 350 Neurophysiology (non-lab section of NEUR 351)NEUR 425 Systems NeuroscienceNEUR 450 Seminar in PhysiologyBIOL 221 Developmental Biology (w/ lab)BIOL 241 Genetic Analysis (w/ lab)BIOL 251 Molecular Genetics (w/ lab)BIOL 260 Animal PhysiologyBIOL 271 Microbiology (w/ lab)BIOL 281 Animal Behavior (w/ lab)BIOL 291 Cell Structure and Function (w/ lab)BIOL 331 Biochemistry (w/ lab)BIOL 381 Genome Biology (w/ lab)BIOL/NEUR 411 Seminar in Synapses: Synaptic Development and PlasticityPSYC 233 Cognitive PsychologyPSYC 234 MemoryPSYC 236 Psychology of AgingPSYC 357 History of Psychiatry

* On leave 2022-23.† On leave fall semester 2022-23. ‡ On leave spring semester 2022-23.

211 Cognitive Neuroscience

(Offered as PSYC 211 and NEUR 211) Historically, psychologists and neuroscientists have worked somewhat in parallel to one another. While psychologists have traditionally focused on how humans think, feel, and behave, neuroscientists have primarily focused exclusively on the workings of the brain. Cognitive neuroscience is a relatively new discipline that lies at the intersection of these fields and seeks to understand the neurobiological processes that underlie cognition. This course serves as a broad introduction to the field of cognitive neuroscience and will focus on a variety of questions, including the following: How does the brain obtain and process information about the environment via sight, taste, and touch? How does the brain support our capacity to learn and speak different languages? What happens to the brain when it is afflicted with neurological disorders such as Alzheimer’s, amnesia, schizophrenia, and autism? This course will provide students with a foundational understanding of modern cognitive neuroscience and the ways in which researchers examine the relationship between the mind and the brain.

Requisite: PSYC 100 or consent of the instructor. Limited to 40 students. Offered Fall 2022: Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2020, Fall 2020, Fall 2022, Fall 2023

213 Neuroscience: Systems and Behavior

(Offered as PSYC 213 and NEUR 213) This course will examine how brain function regulates a broad range of mental processes and behaviors. We will discuss how neurons work and how the brain obtains information about the environment (sensory systems), regulates an organism’s response to the environment (motor systems), controls basic functions necessary for survival such as eating, drinking, sex, and sleep, and mediates higher cognitive function such as memory and language. We will also consider the consequences of brain malfunction as manifested in various forms of disease and mental illness. Laboratories will include basic neuroanatomy and behavioral experiments. Three class hours and three hours of laboratory per week.

Requisite: BIOL 191 or PSYC 100 or consent of the instructor. Cannot be taken if PSYC 212 has been taken because of substantial overlap between the two courses. Limited to 36 students. Spring semester. Professor Baird.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2019, Spring 2024

214 Neurobiology

(Offered as BIOL 214 and NEUR 214) An introduction to the structure and function of the nervous system, this course explores the basic functions of neurons and synapses as well as neural mechanisms of sensation at molecular, cellular, circuit and system levels. Basic topics in neurobiology and neurophysiology will be covered with emphasis on neuroscience history and understanding how neuroscientists approach the study of the nervous system. Three class hours per week.

Requisite: BIOL 191. Limited to 45 students. Fall and Spring semester. Professors Kim and Roche.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

245 Systems Neuroscience

The course will survey behavioral neurobiological systems. Students will explore recent research findings in areas pertaining to the role of neural circuits in several behavioral processes including but not limited to echolocation, mating, prey location, flight control, spatial navigation, song development in birds, mineral appetites, social functions, aggression, and learning and memory mechanisms in several species. Through instructor supervision, discussion, group presentations, and peer review, each student develops a specific research project that results in a research proposal. The course will place significant emphasis on the development of writing skills. Key goals of the course are to prepare juniors for upper-level seminars and to provide an intensive literature-research and writing experience. This course will count as a Group A/List A elective course for the neuroscience major.

Limited to juniors and seniors who have taken NEUR 226 or NEUR 213/214 or consent of the instructor. Limited to 18 students. Fall semester. Professor Baird.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022

301 Molecular Neurobiology with Lab

(Offered as BIOL 301 and NEUR 301) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain and synapse development as well as neuronal death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will supplement the lectures and also emphasize current molecular techniques utilized in the study of the nervous system. Four classroom hours and three hours of laboratory per week.

While enrolled at the college, students may only take either BIOL/NEUR-301 or BIOL/NEUR-303.

Requisite: Bio 191. Bio/Neur 214 strongly suggested.

Limited to 18 students. Spring semester. Professor Roche.

2022-23: Not offered
Other years: Offered in Fall 2011, Fall 2014, Fall 2015, Fall 2016, Spring 2020, Spring 2021, Spring 2022, Fall 2023

303 Molecular Neurobiology: CURE

(Offered as BIOL 303 and NEUR 303) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain development, from neurogenesis, neurite growth, and synaptogenesis to cell death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will emphasize current molecular techniques utilized in the study of the nervous system. This course is a CURE, a Course-based Undergraduate Research Experience. Students will engage in scientific practice, make novel discoveries, participate in iterative work and collaborate with peers. The goal is to give students an authentic research experience in which they will acquire necessary skills for being a scientist. Four classroom hours and three hours of laboratory per week.

Requisite: BIOL 214 or BIOL 260. Limited to 18 students. Spring semester. Professor Kim.

2022-23: Offered in Spring 2023

317 Neurobiology of Appetite

Although the ingestive act per se is clear and simple, understanding the multifarious influences that are distilled into the decision at any given moment to eat, or not to eat, remains a ponderous challenge for scientists. The obesity epidemic of the last several decades continues to spread across the globe, leading to a rise in metabolic diseases and more pressing need than ever to understand the neurobiological controls of eating and body weight. Through a broad survey of neurobiological research literature, we will explore how various neurobiological systems and behavioral processes influence eating and body weight, including metabolism, neural mechanisms of hunger and satiety, metabolic disorders, dieting, pica, failure to thrive, starvation, taste preference and aversion, obesity, anxiety and depression, food taboos, and all eating disorders. Strong emphasis will be placed on biological mechanisms and controlled laboratory research with both human and animal subjects.

Limited to 20 students. Open to juniors and seniors. Fall semester. Prof. Baird.  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Fall 2023

325 Psychopharmacology

(Offered as PSYC 325 and NEUR 325) In this course we will examine the ways in which drugs act on the brain to alter behavior. We will review basic principles of brain function and mechanisms of drug action in the brain. We will discuss a variety of legal and illegal recreational drugs as well as the use of psychotherapeutic drugs to treat mental illness. Examples from the primary scientific literature will demonstrate the various methods used to investigate mechanisms of drug action, the biological and behavioral consequences of drug use, and the nature of efforts to prevent or treat drug abuse.

Requisite: PSYC 212/NEUR 213, or consent of the instructor. Limited to 18 students. Not open to five college students. Spring semester. Professor Turgeon.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Spring 2018, Spring 2019, Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

351 Neurophysiology with Lab

(Offered as BIOL 351 and NEUR 351) This laboratory course will provide a deeper understanding of the physiological properties of the nervous system. We will address the mechanisms underlying electrical activity in neurons, as well as examine the physiology of synapses; the transduction and integration of sensory information; the function of nerve circuits; the trophic and plastic properties of neurons; and the relationship between neuronal activity and behavior. Laboratories will apply electrophysiological methods to examine neuronal activity and will include experimental design as well as analysis and presentation of collected data. Throughout the course, we will focus on past and current neurophysiology research and how it contributes to the field of neuroscience. Three hours of laboratory work per week.

Requisites: BIOL 191 and CHEM 151; PHYS 117 or 124 is recommended. Limited to one lab section with 18 students. Open to juniors and seniors. Fall semester. Professor Trapani.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2012, Fall 2013, Fall 2016, Fall 2022

361 Consciousness and the Brain

(Offered as PSYC 361 and NEUR 361) Although curiosity about the nature of consciousness has animated the work of philosophers, artists and others, this course will approach the topic from a scientific perspective. How do electrochemical signals in our brain produce our experience of colors, sounds, tastes and our awareness of ourselves? We will read and discuss primary source scientific journal articles drawn from both psychology and neuroscience with a focus on questions including: What kinds of brain activity distinguish conscious from unconscious states? Can objects in the environment (e.g., advertisements) affect our behavior even if we are not consciously aware of those objects? Are there different types of consciousness? Is consciousness peculiar to human beings (does it require language?) or is consciousness experienced by other species, as well? Does science have the tools necessary to achieve a complete understanding of human consciousness? Overall, the goal of this course is to provide students with a thorough understanding of the current states of the scientific study of consciousness.

Requisite: PSYC 211, PSYC 212, PSYC 233, or PSYC/NEUR 213. Limited to 18 students. Offered Fall semester. Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2018, Fall 2019, Spring 2021, Fall 2022, Fall 2023

367 Human Neuroscience

(Offered as PSYC 367 and NEUR 367) This course will be an in-depth exploration of contemporary issues in the field of human neuroscience. Topics include a rigorous examination of the methods neuroscientists use to study the human brain, how the brain changes throughout the lifespan, the ways in which researchers have developed brain/machine interfaces, and the neural processes that support decision-making. For each topic, we will read several empirical articles and discuss them with an emphasis on experimental design, factors that may be confounding the data, and interpretation of the data. Assignments will include weekly response papers, an oral presentation, in-class debates, and a research proposal. Overall, the goal of this course is for students to gain an understanding of the cutting edge of human neuroscience research and to increase their ability to think like scientists.

Requisite: PSYC 211 or PSYC 212 or PSYC/NEUR 213 or consent of the instructor. Limited to 18 students. Offered spring semester. Professor Cohen.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2020, Spring 2021, Spring 2024

390 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2007, Fall 2008, Fall 2009, Fall 2010, Fall 2011, Fall 2022

391 Quantitative Imaging with Lab: From Molecules to Cells and Beyond

(Offered as BIOL 391, BCBP 391, and NEUR-391) Fluorescence imaging offers a window to understanding the structure and function of living cells at sub-cellular resolution. This laboratory and lecture course will focus on advanced quantitative fluorescence microscopy techniques used for imaging a range of biological model systems and functions ranging from single molecules to cells to tissues. Students will learn the fundamentals of optics and microscopy and gain hands-on experience with classical and emerging imaging technology including: confocal microscopy, deconvolution and super-resolution methods, and live-cell imaging. Fluorescent probes and genetically encoded biosensors will be discussed and used to study dynamic cellular processes. In addition, the class will explore a range of image processing and analysis workflows. Lectures dealing with the theory, mechanics, and application of fluorescent imaging methods will be intermingled with extended laboratory sessions in our new Amherst Biological Imaging Center.

Pre requisites : BIOL 191 and PHYS 117 and one of BIOL/BCBP291, BIOL221 or BIOL/NEUR 301, or with instructor permission.

There will be two 80-minute lectures and a weekly laboratory. Limited to 12 students. Fall semester. Professors Edwards and Kim  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Spring 2024

450 Seminar in Physiology: Classic Papers in Neurophysiology

(Offered as BIOL 450 and NEUR 450) Concentrating on reading and interpreting primary research, this course will focus on classic and soon-to-be classic neurophysiology papers. We will discuss the seminal experiments performed in the 1950s that led to our understanding of action potentials; experiments in the 1960s and 1970s that unlocked how synapses function; and more recent research that combines electrophysiology with optical methods and genetic techniques to investigate the role of many of the molecular components predicted by the work from the earlier decades. Assignments will include written reviews of literature as well as oral presentations.

Requisite: PHYS 117 or PHYS 124 and one of BIOL-214, BIOL 260, BIOL 350/351, or consent of the instructor. Limited to 18 students. Not open to first-year students. Spring Semester. Professor Trapani.

2022-23: Not offered
Other years: Offered in Spring 2013, Spring 2017, Spring 2019, Spring 2022, Spring 2024

490 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2013, Spring 2014, Fall 2014, Spring 2015, Fall 2015, Spring 2016, Fall 2016, Spring 2017, Fall 2017, Spring 2018, Fall 2018, Spring 2019, Fall 2019, Spring 2020, Fall 2020, Spring 2021, Fall 2021, Spring 2022, Fall 2022

498, 498D, 499, 499D Senior Departmental Honors

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research.

Fall semester. The Committee.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Fall 2017, Fall 2018, Fall 2019, Fall 2020, January 2021, Fall 2021, Fall 2022, Fall 2023
Department Website

Regulations & Requirements

Back

Neuroscience

Neuroscience Advisory Committee: Professors Baird, Cohen, Kim, Trapani, Turgeon (Chair), Visiting Assistant Professor Roche.

Affiliated Faculty: Professors Clotfelter and Goutte.

The Neuroscience major consists of science courses in Biology, Chemistry, Mathematics, Physics, and Psychology, plus senior comprehensives, which includes attending neuroscience seminars and a comprehensive examination. Neuroscience majors may also choose to do a senior honors research project in the laboratory of a Neuroscience faculty member or affiliated Biology faculty member (and in some cases a faculty member from UMass-Amherst). Neuroscience majors must preregister for all courses that they will use to satisfy requirements for the major, rather than assume they will be guaranteed entry into a course during the add/drop period (e.g., you must preregister for NEUR 301 and/or NEUR 351). Courses in which a student has not received a letter grade better than "D" are not counted towards the Neuroscience major.

To receive Advanced Placement (AP) in a neuroscience course, you must have fulfilled the following requirements:

Chemistry: with a Chemistry AP score of 4 or 5, follow the recommendation made during orientation (many students with AP credit still take CHEM 151).Math: you may place out MATH 111 with a score of 4 or 5 on the AB exam or a 3 on the BC exam. In this case, you still need to satisfy the Physics/Mathematics requirement with a higher-level.Biology: you may place out of BIOL 191 with a score of 5 on the Biology AP exam. In this case you must substitute BIOL 251 or BIOL 291 for BIOL 191.

Neuroscience majors must complete the following requirements:

(1) General science requirements:

Chemistry: All of the following:

CHEM 151 (or 155)CHEM 161CHEM 221 (most majors also take CHEM 231)

Biology:

BIOL 191Note: BIOL 181 is optional for Neuroscience, but should be considered by students in their first year that are considering majoring in Biology or Neuroscience but haven't decided between them yet.

Statistics: One of the following:

STAT 111 (formerly MATH 130) orMATH/STAT 135 orSTAT 230 (formerly MATH 230) orBIOL 210 orPSYC 122

Physics/Mathematics: At least two of the following courses:

PHYS 116, 117, 123, 124MATH 111, 121, 211If you have Advanced Placement in any of these subjects, take more advanced courses.MATH 111 or Advanced Placement (at least 4 on AB or 3 on BC) is a prerequisite for CHEM 161 and PHYS 117.The Statistics requirement above is a separate requirement and does not count towards this Physics/Math requirement.

(2) Introduction to Neuroscience course:

Neuroscience Majors must take the following two courses:

NEUR 213: Neuroscience: Systems and Behavior (with lab)NEUR 214: Neurobiology (non lab)Note: The NEUR 213 course must be taken in the spring semester of your sophomore year. The NEUR 214 course may be taken in the fall of either sophomore or junior year but must be completed prior to the end of junior year.

(3) Upper-level Behavioral Neuroscience:

One of the following seminar courses:

NEUR 325 PsychopharmacologyNEUR 356 Neurophysiology of Motivation

(4) Upper-level Cellular/Molecular Neuroscience:

One of the following lab courses:

NEUR 301 Molecular Neurobiology with laboratoryNEUR 351 Neurophysiology with laboratory

(5) Upper-level Human Neuroscience:

Neuroscience Majors must take one of the following courses:

NEUR 361 Consciousness and the BrainNEUR 367 Human Neuroscience

(6) Upper-level Elective:

One additional upper-level elective from the following courses:

An additional behavioral neuroscience course from item (3) aboveAn additional molecular/cellular neuroscience course from item (4) aboveAn additional human neuroscience course from item (5) aboveNEUR 350 Neurophysiology (non-lab section of NEUR 351)NEUR 425 Systems NeuroscienceNEUR 450 Seminar in PhysiologyBIOL 221 Developmental Biology (w/ lab)BIOL 241 Genetic Analysis (w/ lab)BIOL 251 Molecular Genetics (w/ lab)BIOL 260 Animal PhysiologyBIOL 271 Microbiology (w/ lab)BIOL 281 Animal Behavior (w/ lab)BIOL 291 Cell Structure and Function (w/ lab)BIOL 331 Biochemistry (w/ lab)BIOL 381 Genome Biology (w/ lab)BIOL/NEUR 411 Seminar in Synapses: Synaptic Development and PlasticityPSYC 233 Cognitive PsychologyPSYC 234 MemoryPSYC 236 Psychology of AgingPSYC 357 History of Psychiatry

* On leave 2022-23.† On leave fall semester 2022-23. ‡ On leave spring semester 2022-23.

211 Cognitive Neuroscience

(Offered as PSYC 211 and NEUR 211) Historically, psychologists and neuroscientists have worked somewhat in parallel to one another. While psychologists have traditionally focused on how humans think, feel, and behave, neuroscientists have primarily focused exclusively on the workings of the brain. Cognitive neuroscience is a relatively new discipline that lies at the intersection of these fields and seeks to understand the neurobiological processes that underlie cognition. This course serves as a broad introduction to the field of cognitive neuroscience and will focus on a variety of questions, including the following: How does the brain obtain and process information about the environment via sight, taste, and touch? How does the brain support our capacity to learn and speak different languages? What happens to the brain when it is afflicted with neurological disorders such as Alzheimer’s, amnesia, schizophrenia, and autism? This course will provide students with a foundational understanding of modern cognitive neuroscience and the ways in which researchers examine the relationship between the mind and the brain.

Requisite: PSYC 100 or consent of the instructor. Limited to 40 students. Offered Fall 2022: Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2020, Fall 2020, Fall 2022, Fall 2023

213 Neuroscience: Systems and Behavior

(Offered as PSYC 213 and NEUR 213) This course will examine how brain function regulates a broad range of mental processes and behaviors. We will discuss how neurons work and how the brain obtains information about the environment (sensory systems), regulates an organism’s response to the environment (motor systems), controls basic functions necessary for survival such as eating, drinking, sex, and sleep, and mediates higher cognitive function such as memory and language. We will also consider the consequences of brain malfunction as manifested in various forms of disease and mental illness. Laboratories will include basic neuroanatomy and behavioral experiments. Three class hours and three hours of laboratory per week.

Requisite: BIOL 191 or PSYC 100 or consent of the instructor. Cannot be taken if PSYC 212 has been taken because of substantial overlap between the two courses. Limited to 36 students. Spring semester. Professor Baird.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2019, Spring 2024

214 Neurobiology

(Offered as BIOL 214 and NEUR 214) An introduction to the structure and function of the nervous system, this course explores the basic functions of neurons and synapses as well as neural mechanisms of sensation at molecular, cellular, circuit and system levels. Basic topics in neurobiology and neurophysiology will be covered with emphasis on neuroscience history and understanding how neuroscientists approach the study of the nervous system. Three class hours per week.

Requisite: BIOL 191. Limited to 45 students. Fall and Spring semester. Professors Kim and Roche.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

245 Systems Neuroscience

The course will survey behavioral neurobiological systems. Students will explore recent research findings in areas pertaining to the role of neural circuits in several behavioral processes including but not limited to echolocation, mating, prey location, flight control, spatial navigation, song development in birds, mineral appetites, social functions, aggression, and learning and memory mechanisms in several species. Through instructor supervision, discussion, group presentations, and peer review, each student develops a specific research project that results in a research proposal. The course will place significant emphasis on the development of writing skills. Key goals of the course are to prepare juniors for upper-level seminars and to provide an intensive literature-research and writing experience. This course will count as a Group A/List A elective course for the neuroscience major.

Limited to juniors and seniors who have taken NEUR 226 or NEUR 213/214 or consent of the instructor. Limited to 18 students. Fall semester. Professor Baird.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022

301 Molecular Neurobiology with Lab

(Offered as BIOL 301 and NEUR 301) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain and synapse development as well as neuronal death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will supplement the lectures and also emphasize current molecular techniques utilized in the study of the nervous system. Four classroom hours and three hours of laboratory per week.

While enrolled at the college, students may only take either BIOL/NEUR-301 or BIOL/NEUR-303.

Requisite: Bio 191. Bio/Neur 214 strongly suggested.

Limited to 18 students. Spring semester. Professor Roche.

2022-23: Not offered
Other years: Offered in Fall 2011, Fall 2014, Fall 2015, Fall 2016, Spring 2020, Spring 2021, Spring 2022, Fall 2023

303 Molecular Neurobiology: CURE

(Offered as BIOL 303 and NEUR 303) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain development, from neurogenesis, neurite growth, and synaptogenesis to cell death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will emphasize current molecular techniques utilized in the study of the nervous system. This course is a CURE, a Course-based Undergraduate Research Experience. Students will engage in scientific practice, make novel discoveries, participate in iterative work and collaborate with peers. The goal is to give students an authentic research experience in which they will acquire necessary skills for being a scientist. Four classroom hours and three hours of laboratory per week.

Requisite: BIOL 214 or BIOL 260. Limited to 18 students. Spring semester. Professor Kim.

2022-23: Offered in Spring 2023

317 Neurobiology of Appetite

Although the ingestive act per se is clear and simple, understanding the multifarious influences that are distilled into the decision at any given moment to eat, or not to eat, remains a ponderous challenge for scientists. The obesity epidemic of the last several decades continues to spread across the globe, leading to a rise in metabolic diseases and more pressing need than ever to understand the neurobiological controls of eating and body weight. Through a broad survey of neurobiological research literature, we will explore how various neurobiological systems and behavioral processes influence eating and body weight, including metabolism, neural mechanisms of hunger and satiety, metabolic disorders, dieting, pica, failure to thrive, starvation, taste preference and aversion, obesity, anxiety and depression, food taboos, and all eating disorders. Strong emphasis will be placed on biological mechanisms and controlled laboratory research with both human and animal subjects.

Limited to 20 students. Open to juniors and seniors. Fall semester. Prof. Baird.  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Fall 2023

325 Psychopharmacology

(Offered as PSYC 325 and NEUR 325) In this course we will examine the ways in which drugs act on the brain to alter behavior. We will review basic principles of brain function and mechanisms of drug action in the brain. We will discuss a variety of legal and illegal recreational drugs as well as the use of psychotherapeutic drugs to treat mental illness. Examples from the primary scientific literature will demonstrate the various methods used to investigate mechanisms of drug action, the biological and behavioral consequences of drug use, and the nature of efforts to prevent or treat drug abuse.

Requisite: PSYC 212/NEUR 213, or consent of the instructor. Limited to 18 students. Not open to five college students. Spring semester. Professor Turgeon.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Spring 2018, Spring 2019, Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

351 Neurophysiology with Lab

(Offered as BIOL 351 and NEUR 351) This laboratory course will provide a deeper understanding of the physiological properties of the nervous system. We will address the mechanisms underlying electrical activity in neurons, as well as examine the physiology of synapses; the transduction and integration of sensory information; the function of nerve circuits; the trophic and plastic properties of neurons; and the relationship between neuronal activity and behavior. Laboratories will apply electrophysiological methods to examine neuronal activity and will include experimental design as well as analysis and presentation of collected data. Throughout the course, we will focus on past and current neurophysiology research and how it contributes to the field of neuroscience. Three hours of laboratory work per week.

Requisites: BIOL 191 and CHEM 151; PHYS 117 or 124 is recommended. Limited to one lab section with 18 students. Open to juniors and seniors. Fall semester. Professor Trapani.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2012, Fall 2013, Fall 2016, Fall 2022

361 Consciousness and the Brain

(Offered as PSYC 361 and NEUR 361) Although curiosity about the nature of consciousness has animated the work of philosophers, artists and others, this course will approach the topic from a scientific perspective. How do electrochemical signals in our brain produce our experience of colors, sounds, tastes and our awareness of ourselves? We will read and discuss primary source scientific journal articles drawn from both psychology and neuroscience with a focus on questions including: What kinds of brain activity distinguish conscious from unconscious states? Can objects in the environment (e.g., advertisements) affect our behavior even if we are not consciously aware of those objects? Are there different types of consciousness? Is consciousness peculiar to human beings (does it require language?) or is consciousness experienced by other species, as well? Does science have the tools necessary to achieve a complete understanding of human consciousness? Overall, the goal of this course is to provide students with a thorough understanding of the current states of the scientific study of consciousness.

Requisite: PSYC 211, PSYC 212, PSYC 233, or PSYC/NEUR 213. Limited to 18 students. Offered Fall semester. Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2018, Fall 2019, Spring 2021, Fall 2022, Fall 2023

367 Human Neuroscience

(Offered as PSYC 367 and NEUR 367) This course will be an in-depth exploration of contemporary issues in the field of human neuroscience. Topics include a rigorous examination of the methods neuroscientists use to study the human brain, how the brain changes throughout the lifespan, the ways in which researchers have developed brain/machine interfaces, and the neural processes that support decision-making. For each topic, we will read several empirical articles and discuss them with an emphasis on experimental design, factors that may be confounding the data, and interpretation of the data. Assignments will include weekly response papers, an oral presentation, in-class debates, and a research proposal. Overall, the goal of this course is for students to gain an understanding of the cutting edge of human neuroscience research and to increase their ability to think like scientists.

Requisite: PSYC 211 or PSYC 212 or PSYC/NEUR 213 or consent of the instructor. Limited to 18 students. Offered spring semester. Professor Cohen.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2020, Spring 2021, Spring 2024

390 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2007, Fall 2008, Fall 2009, Fall 2010, Fall 2011, Fall 2022

391 Quantitative Imaging with Lab: From Molecules to Cells and Beyond

(Offered as BIOL 391, BCBP 391, and NEUR-391) Fluorescence imaging offers a window to understanding the structure and function of living cells at sub-cellular resolution. This laboratory and lecture course will focus on advanced quantitative fluorescence microscopy techniques used for imaging a range of biological model systems and functions ranging from single molecules to cells to tissues. Students will learn the fundamentals of optics and microscopy and gain hands-on experience with classical and emerging imaging technology including: confocal microscopy, deconvolution and super-resolution methods, and live-cell imaging. Fluorescent probes and genetically encoded biosensors will be discussed and used to study dynamic cellular processes. In addition, the class will explore a range of image processing and analysis workflows. Lectures dealing with the theory, mechanics, and application of fluorescent imaging methods will be intermingled with extended laboratory sessions in our new Amherst Biological Imaging Center.

Pre requisites : BIOL 191 and PHYS 117 and one of BIOL/BCBP291, BIOL221 or BIOL/NEUR 301, or with instructor permission.

There will be two 80-minute lectures and a weekly laboratory. Limited to 12 students. Fall semester. Professors Edwards and Kim  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Spring 2024

450 Seminar in Physiology: Classic Papers in Neurophysiology

(Offered as BIOL 450 and NEUR 450) Concentrating on reading and interpreting primary research, this course will focus on classic and soon-to-be classic neurophysiology papers. We will discuss the seminal experiments performed in the 1950s that led to our understanding of action potentials; experiments in the 1960s and 1970s that unlocked how synapses function; and more recent research that combines electrophysiology with optical methods and genetic techniques to investigate the role of many of the molecular components predicted by the work from the earlier decades. Assignments will include written reviews of literature as well as oral presentations.

Requisite: PHYS 117 or PHYS 124 and one of BIOL-214, BIOL 260, BIOL 350/351, or consent of the instructor. Limited to 18 students. Not open to first-year students. Spring Semester. Professor Trapani.

2022-23: Not offered
Other years: Offered in Spring 2013, Spring 2017, Spring 2019, Spring 2022, Spring 2024

490 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2013, Spring 2014, Fall 2014, Spring 2015, Fall 2015, Spring 2016, Fall 2016, Spring 2017, Fall 2017, Spring 2018, Fall 2018, Spring 2019, Fall 2019, Spring 2020, Fall 2020, Spring 2021, Fall 2021, Spring 2022, Fall 2022

498, 498D, 499, 499D Senior Departmental Honors

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research.

Fall semester. The Committee.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Fall 2017, Fall 2018, Fall 2019, Fall 2020, January 2021, Fall 2021, Fall 2022, Fall 2023
Department Website

Amherst College Courses

Back

Neuroscience

Neuroscience Advisory Committee: Professors Baird, Cohen, Kim, Trapani, Turgeon (Chair), Visiting Assistant Professor Roche.

Affiliated Faculty: Professors Clotfelter and Goutte.

The Neuroscience major consists of science courses in Biology, Chemistry, Mathematics, Physics, and Psychology, plus senior comprehensives, which includes attending neuroscience seminars and a comprehensive examination. Neuroscience majors may also choose to do a senior honors research project in the laboratory of a Neuroscience faculty member or affiliated Biology faculty member (and in some cases a faculty member from UMass-Amherst). Neuroscience majors must preregister for all courses that they will use to satisfy requirements for the major, rather than assume they will be guaranteed entry into a course during the add/drop period (e.g., you must preregister for NEUR 301 and/or NEUR 351). Courses in which a student has not received a letter grade better than "D" are not counted towards the Neuroscience major.

To receive Advanced Placement (AP) in a neuroscience course, you must have fulfilled the following requirements:

Chemistry: with a Chemistry AP score of 4 or 5, follow the recommendation made during orientation (many students with AP credit still take CHEM 151).Math: you may place out MATH 111 with a score of 4 or 5 on the AB exam or a 3 on the BC exam. In this case, you still need to satisfy the Physics/Mathematics requirement with a higher-level.Biology: you may place out of BIOL 191 with a score of 5 on the Biology AP exam. In this case you must substitute BIOL 251 or BIOL 291 for BIOL 191.

Neuroscience majors must complete the following requirements:

(1) General science requirements:

Chemistry: All of the following:

CHEM 151 (or 155)CHEM 161CHEM 221 (most majors also take CHEM 231)

Biology:

BIOL 191Note: BIOL 181 is optional for Neuroscience, but should be considered by students in their first year that are considering majoring in Biology or Neuroscience but haven't decided between them yet.

Statistics: One of the following:

STAT 111 (formerly MATH 130) orMATH/STAT 135 orSTAT 230 (formerly MATH 230) orBIOL 210 orPSYC 122

Physics/Mathematics: At least two of the following courses:

PHYS 116, 117, 123, 124MATH 111, 121, 211If you have Advanced Placement in any of these subjects, take more advanced courses.MATH 111 or Advanced Placement (at least 4 on AB or 3 on BC) is a prerequisite for CHEM 161 and PHYS 117.The Statistics requirement above is a separate requirement and does not count towards this Physics/Math requirement.

(2) Introduction to Neuroscience course:

Neuroscience Majors must take the following two courses:

NEUR 213: Neuroscience: Systems and Behavior (with lab)NEUR 214: Neurobiology (non lab)Note: The NEUR 213 course must be taken in the spring semester of your sophomore year. The NEUR 214 course may be taken in the fall of either sophomore or junior year but must be completed prior to the end of junior year.

(3) Upper-level Behavioral Neuroscience:

One of the following seminar courses:

NEUR 325 PsychopharmacologyNEUR 356 Neurophysiology of Motivation

(4) Upper-level Cellular/Molecular Neuroscience:

One of the following lab courses:

NEUR 301 Molecular Neurobiology with laboratoryNEUR 351 Neurophysiology with laboratory

(5) Upper-level Human Neuroscience:

Neuroscience Majors must take one of the following courses:

NEUR 361 Consciousness and the BrainNEUR 367 Human Neuroscience

(6) Upper-level Elective:

One additional upper-level elective from the following courses:

An additional behavioral neuroscience course from item (3) aboveAn additional molecular/cellular neuroscience course from item (4) aboveAn additional human neuroscience course from item (5) aboveNEUR 350 Neurophysiology (non-lab section of NEUR 351)NEUR 425 Systems NeuroscienceNEUR 450 Seminar in PhysiologyBIOL 221 Developmental Biology (w/ lab)BIOL 241 Genetic Analysis (w/ lab)BIOL 251 Molecular Genetics (w/ lab)BIOL 260 Animal PhysiologyBIOL 271 Microbiology (w/ lab)BIOL 281 Animal Behavior (w/ lab)BIOL 291 Cell Structure and Function (w/ lab)BIOL 331 Biochemistry (w/ lab)BIOL 381 Genome Biology (w/ lab)BIOL/NEUR 411 Seminar in Synapses: Synaptic Development and PlasticityPSYC 233 Cognitive PsychologyPSYC 234 MemoryPSYC 236 Psychology of AgingPSYC 357 History of Psychiatry

* On leave 2022-23.† On leave fall semester 2022-23. ‡ On leave spring semester 2022-23.

211 Cognitive Neuroscience

(Offered as PSYC 211 and NEUR 211) Historically, psychologists and neuroscientists have worked somewhat in parallel to one another. While psychologists have traditionally focused on how humans think, feel, and behave, neuroscientists have primarily focused exclusively on the workings of the brain. Cognitive neuroscience is a relatively new discipline that lies at the intersection of these fields and seeks to understand the neurobiological processes that underlie cognition. This course serves as a broad introduction to the field of cognitive neuroscience and will focus on a variety of questions, including the following: How does the brain obtain and process information about the environment via sight, taste, and touch? How does the brain support our capacity to learn and speak different languages? What happens to the brain when it is afflicted with neurological disorders such as Alzheimer’s, amnesia, schizophrenia, and autism? This course will provide students with a foundational understanding of modern cognitive neuroscience and the ways in which researchers examine the relationship between the mind and the brain.

Requisite: PSYC 100 or consent of the instructor. Limited to 40 students. Offered Fall 2022: Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2020, Fall 2020, Fall 2022, Fall 2023

213 Neuroscience: Systems and Behavior

(Offered as PSYC 213 and NEUR 213) This course will examine how brain function regulates a broad range of mental processes and behaviors. We will discuss how neurons work and how the brain obtains information about the environment (sensory systems), regulates an organism’s response to the environment (motor systems), controls basic functions necessary for survival such as eating, drinking, sex, and sleep, and mediates higher cognitive function such as memory and language. We will also consider the consequences of brain malfunction as manifested in various forms of disease and mental illness. Laboratories will include basic neuroanatomy and behavioral experiments. Three class hours and three hours of laboratory per week.

Requisite: BIOL 191 or PSYC 100 or consent of the instructor. Cannot be taken if PSYC 212 has been taken because of substantial overlap between the two courses. Limited to 36 students. Spring semester. Professor Baird.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2019, Spring 2024

214 Neurobiology

(Offered as BIOL 214 and NEUR 214) An introduction to the structure and function of the nervous system, this course explores the basic functions of neurons and synapses as well as neural mechanisms of sensation at molecular, cellular, circuit and system levels. Basic topics in neurobiology and neurophysiology will be covered with emphasis on neuroscience history and understanding how neuroscientists approach the study of the nervous system. Three class hours per week.

Requisite: BIOL 191. Limited to 45 students. Fall and Spring semester. Professors Kim and Roche.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

245 Systems Neuroscience

The course will survey behavioral neurobiological systems. Students will explore recent research findings in areas pertaining to the role of neural circuits in several behavioral processes including but not limited to echolocation, mating, prey location, flight control, spatial navigation, song development in birds, mineral appetites, social functions, aggression, and learning and memory mechanisms in several species. Through instructor supervision, discussion, group presentations, and peer review, each student develops a specific research project that results in a research proposal. The course will place significant emphasis on the development of writing skills. Key goals of the course are to prepare juniors for upper-level seminars and to provide an intensive literature-research and writing experience. This course will count as a Group A/List A elective course for the neuroscience major.

Limited to juniors and seniors who have taken NEUR 226 or NEUR 213/214 or consent of the instructor. Limited to 18 students. Fall semester. Professor Baird.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022

301 Molecular Neurobiology with Lab

(Offered as BIOL 301 and NEUR 301) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain and synapse development as well as neuronal death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will supplement the lectures and also emphasize current molecular techniques utilized in the study of the nervous system. Four classroom hours and three hours of laboratory per week.

While enrolled at the college, students may only take either BIOL/NEUR-301 or BIOL/NEUR-303.

Requisite: Bio 191. Bio/Neur 214 strongly suggested.

Limited to 18 students. Spring semester. Professor Roche.

2022-23: Not offered
Other years: Offered in Fall 2011, Fall 2014, Fall 2015, Fall 2016, Spring 2020, Spring 2021, Spring 2022, Fall 2023

303 Molecular Neurobiology: CURE

(Offered as BIOL 303 and NEUR 303) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain development, from neurogenesis, neurite growth, and synaptogenesis to cell death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will emphasize current molecular techniques utilized in the study of the nervous system. This course is a CURE, a Course-based Undergraduate Research Experience. Students will engage in scientific practice, make novel discoveries, participate in iterative work and collaborate with peers. The goal is to give students an authentic research experience in which they will acquire necessary skills for being a scientist. Four classroom hours and three hours of laboratory per week.

Requisite: BIOL 214 or BIOL 260. Limited to 18 students. Spring semester. Professor Kim.

2022-23: Offered in Spring 2023

317 Neurobiology of Appetite

Although the ingestive act per se is clear and simple, understanding the multifarious influences that are distilled into the decision at any given moment to eat, or not to eat, remains a ponderous challenge for scientists. The obesity epidemic of the last several decades continues to spread across the globe, leading to a rise in metabolic diseases and more pressing need than ever to understand the neurobiological controls of eating and body weight. Through a broad survey of neurobiological research literature, we will explore how various neurobiological systems and behavioral processes influence eating and body weight, including metabolism, neural mechanisms of hunger and satiety, metabolic disorders, dieting, pica, failure to thrive, starvation, taste preference and aversion, obesity, anxiety and depression, food taboos, and all eating disorders. Strong emphasis will be placed on biological mechanisms and controlled laboratory research with both human and animal subjects.

Limited to 20 students. Open to juniors and seniors. Fall semester. Prof. Baird.  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Fall 2023

325 Psychopharmacology

(Offered as PSYC 325 and NEUR 325) In this course we will examine the ways in which drugs act on the brain to alter behavior. We will review basic principles of brain function and mechanisms of drug action in the brain. We will discuss a variety of legal and illegal recreational drugs as well as the use of psychotherapeutic drugs to treat mental illness. Examples from the primary scientific literature will demonstrate the various methods used to investigate mechanisms of drug action, the biological and behavioral consequences of drug use, and the nature of efforts to prevent or treat drug abuse.

Requisite: PSYC 212/NEUR 213, or consent of the instructor. Limited to 18 students. Not open to five college students. Spring semester. Professor Turgeon.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Spring 2018, Spring 2019, Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

351 Neurophysiology with Lab

(Offered as BIOL 351 and NEUR 351) This laboratory course will provide a deeper understanding of the physiological properties of the nervous system. We will address the mechanisms underlying electrical activity in neurons, as well as examine the physiology of synapses; the transduction and integration of sensory information; the function of nerve circuits; the trophic and plastic properties of neurons; and the relationship between neuronal activity and behavior. Laboratories will apply electrophysiological methods to examine neuronal activity and will include experimental design as well as analysis and presentation of collected data. Throughout the course, we will focus on past and current neurophysiology research and how it contributes to the field of neuroscience. Three hours of laboratory work per week.

Requisites: BIOL 191 and CHEM 151; PHYS 117 or 124 is recommended. Limited to one lab section with 18 students. Open to juniors and seniors. Fall semester. Professor Trapani.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2012, Fall 2013, Fall 2016, Fall 2022

361 Consciousness and the Brain

(Offered as PSYC 361 and NEUR 361) Although curiosity about the nature of consciousness has animated the work of philosophers, artists and others, this course will approach the topic from a scientific perspective. How do electrochemical signals in our brain produce our experience of colors, sounds, tastes and our awareness of ourselves? We will read and discuss primary source scientific journal articles drawn from both psychology and neuroscience with a focus on questions including: What kinds of brain activity distinguish conscious from unconscious states? Can objects in the environment (e.g., advertisements) affect our behavior even if we are not consciously aware of those objects? Are there different types of consciousness? Is consciousness peculiar to human beings (does it require language?) or is consciousness experienced by other species, as well? Does science have the tools necessary to achieve a complete understanding of human consciousness? Overall, the goal of this course is to provide students with a thorough understanding of the current states of the scientific study of consciousness.

Requisite: PSYC 211, PSYC 212, PSYC 233, or PSYC/NEUR 213. Limited to 18 students. Offered Fall semester. Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2018, Fall 2019, Spring 2021, Fall 2022, Fall 2023

367 Human Neuroscience

(Offered as PSYC 367 and NEUR 367) This course will be an in-depth exploration of contemporary issues in the field of human neuroscience. Topics include a rigorous examination of the methods neuroscientists use to study the human brain, how the brain changes throughout the lifespan, the ways in which researchers have developed brain/machine interfaces, and the neural processes that support decision-making. For each topic, we will read several empirical articles and discuss them with an emphasis on experimental design, factors that may be confounding the data, and interpretation of the data. Assignments will include weekly response papers, an oral presentation, in-class debates, and a research proposal. Overall, the goal of this course is for students to gain an understanding of the cutting edge of human neuroscience research and to increase their ability to think like scientists.

Requisite: PSYC 211 or PSYC 212 or PSYC/NEUR 213 or consent of the instructor. Limited to 18 students. Offered spring semester. Professor Cohen.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2020, Spring 2021, Spring 2024

390 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2007, Fall 2008, Fall 2009, Fall 2010, Fall 2011, Fall 2022

391 Quantitative Imaging with Lab: From Molecules to Cells and Beyond

(Offered as BIOL 391, BCBP 391, and NEUR-391) Fluorescence imaging offers a window to understanding the structure and function of living cells at sub-cellular resolution. This laboratory and lecture course will focus on advanced quantitative fluorescence microscopy techniques used for imaging a range of biological model systems and functions ranging from single molecules to cells to tissues. Students will learn the fundamentals of optics and microscopy and gain hands-on experience with classical and emerging imaging technology including: confocal microscopy, deconvolution and super-resolution methods, and live-cell imaging. Fluorescent probes and genetically encoded biosensors will be discussed and used to study dynamic cellular processes. In addition, the class will explore a range of image processing and analysis workflows. Lectures dealing with the theory, mechanics, and application of fluorescent imaging methods will be intermingled with extended laboratory sessions in our new Amherst Biological Imaging Center.

Pre requisites : BIOL 191 and PHYS 117 and one of BIOL/BCBP291, BIOL221 or BIOL/NEUR 301, or with instructor permission.

There will be two 80-minute lectures and a weekly laboratory. Limited to 12 students. Fall semester. Professors Edwards and Kim  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Spring 2024

450 Seminar in Physiology: Classic Papers in Neurophysiology

(Offered as BIOL 450 and NEUR 450) Concentrating on reading and interpreting primary research, this course will focus on classic and soon-to-be classic neurophysiology papers. We will discuss the seminal experiments performed in the 1950s that led to our understanding of action potentials; experiments in the 1960s and 1970s that unlocked how synapses function; and more recent research that combines electrophysiology with optical methods and genetic techniques to investigate the role of many of the molecular components predicted by the work from the earlier decades. Assignments will include written reviews of literature as well as oral presentations.

Requisite: PHYS 117 or PHYS 124 and one of BIOL-214, BIOL 260, BIOL 350/351, or consent of the instructor. Limited to 18 students. Not open to first-year students. Spring Semester. Professor Trapani.

2022-23: Not offered
Other years: Offered in Spring 2013, Spring 2017, Spring 2019, Spring 2022, Spring 2024

490 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2013, Spring 2014, Fall 2014, Spring 2015, Fall 2015, Spring 2016, Fall 2016, Spring 2017, Fall 2017, Spring 2018, Fall 2018, Spring 2019, Fall 2019, Spring 2020, Fall 2020, Spring 2021, Fall 2021, Spring 2022, Fall 2022

498, 498D, 499, 499D Senior Departmental Honors

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research.

Fall semester. The Committee.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Fall 2017, Fall 2018, Fall 2019, Fall 2020, January 2021, Fall 2021, Fall 2022, Fall 2023
Department Website

Five College Programs & Certificates

Back

Neuroscience

Neuroscience Advisory Committee: Professors Baird, Cohen, Kim, Trapani, Turgeon (Chair), Visiting Assistant Professor Roche.

Affiliated Faculty: Professors Clotfelter and Goutte.

The Neuroscience major consists of science courses in Biology, Chemistry, Mathematics, Physics, and Psychology, plus senior comprehensives, which includes attending neuroscience seminars and a comprehensive examination. Neuroscience majors may also choose to do a senior honors research project in the laboratory of a Neuroscience faculty member or affiliated Biology faculty member (and in some cases a faculty member from UMass-Amherst). Neuroscience majors must preregister for all courses that they will use to satisfy requirements for the major, rather than assume they will be guaranteed entry into a course during the add/drop period (e.g., you must preregister for NEUR 301 and/or NEUR 351). Courses in which a student has not received a letter grade better than "D" are not counted towards the Neuroscience major.

To receive Advanced Placement (AP) in a neuroscience course, you must have fulfilled the following requirements:

Chemistry: with a Chemistry AP score of 4 or 5, follow the recommendation made during orientation (many students with AP credit still take CHEM 151).Math: you may place out MATH 111 with a score of 4 or 5 on the AB exam or a 3 on the BC exam. In this case, you still need to satisfy the Physics/Mathematics requirement with a higher-level.Biology: you may place out of BIOL 191 with a score of 5 on the Biology AP exam. In this case you must substitute BIOL 251 or BIOL 291 for BIOL 191.

Neuroscience majors must complete the following requirements:

(1) General science requirements:

Chemistry: All of the following:

CHEM 151 (or 155)CHEM 161CHEM 221 (most majors also take CHEM 231)

Biology:

BIOL 191Note: BIOL 181 is optional for Neuroscience, but should be considered by students in their first year that are considering majoring in Biology or Neuroscience but haven't decided between them yet.

Statistics: One of the following:

STAT 111 (formerly MATH 130) orMATH/STAT 135 orSTAT 230 (formerly MATH 230) orBIOL 210 orPSYC 122

Physics/Mathematics: At least two of the following courses:

PHYS 116, 117, 123, 124MATH 111, 121, 211If you have Advanced Placement in any of these subjects, take more advanced courses.MATH 111 or Advanced Placement (at least 4 on AB or 3 on BC) is a prerequisite for CHEM 161 and PHYS 117.The Statistics requirement above is a separate requirement and does not count towards this Physics/Math requirement.

(2) Introduction to Neuroscience course:

Neuroscience Majors must take the following two courses:

NEUR 213: Neuroscience: Systems and Behavior (with lab)NEUR 214: Neurobiology (non lab)Note: The NEUR 213 course must be taken in the spring semester of your sophomore year. The NEUR 214 course may be taken in the fall of either sophomore or junior year but must be completed prior to the end of junior year.

(3) Upper-level Behavioral Neuroscience:

One of the following seminar courses:

NEUR 325 PsychopharmacologyNEUR 356 Neurophysiology of Motivation

(4) Upper-level Cellular/Molecular Neuroscience:

One of the following lab courses:

NEUR 301 Molecular Neurobiology with laboratoryNEUR 351 Neurophysiology with laboratory

(5) Upper-level Human Neuroscience:

Neuroscience Majors must take one of the following courses:

NEUR 361 Consciousness and the BrainNEUR 367 Human Neuroscience

(6) Upper-level Elective:

One additional upper-level elective from the following courses:

An additional behavioral neuroscience course from item (3) aboveAn additional molecular/cellular neuroscience course from item (4) aboveAn additional human neuroscience course from item (5) aboveNEUR 350 Neurophysiology (non-lab section of NEUR 351)NEUR 425 Systems NeuroscienceNEUR 450 Seminar in PhysiologyBIOL 221 Developmental Biology (w/ lab)BIOL 241 Genetic Analysis (w/ lab)BIOL 251 Molecular Genetics (w/ lab)BIOL 260 Animal PhysiologyBIOL 271 Microbiology (w/ lab)BIOL 281 Animal Behavior (w/ lab)BIOL 291 Cell Structure and Function (w/ lab)BIOL 331 Biochemistry (w/ lab)BIOL 381 Genome Biology (w/ lab)BIOL/NEUR 411 Seminar in Synapses: Synaptic Development and PlasticityPSYC 233 Cognitive PsychologyPSYC 234 MemoryPSYC 236 Psychology of AgingPSYC 357 History of Psychiatry

* On leave 2022-23.† On leave fall semester 2022-23. ‡ On leave spring semester 2022-23.

211 Cognitive Neuroscience

(Offered as PSYC 211 and NEUR 211) Historically, psychologists and neuroscientists have worked somewhat in parallel to one another. While psychologists have traditionally focused on how humans think, feel, and behave, neuroscientists have primarily focused exclusively on the workings of the brain. Cognitive neuroscience is a relatively new discipline that lies at the intersection of these fields and seeks to understand the neurobiological processes that underlie cognition. This course serves as a broad introduction to the field of cognitive neuroscience and will focus on a variety of questions, including the following: How does the brain obtain and process information about the environment via sight, taste, and touch? How does the brain support our capacity to learn and speak different languages? What happens to the brain when it is afflicted with neurological disorders such as Alzheimer’s, amnesia, schizophrenia, and autism? This course will provide students with a foundational understanding of modern cognitive neuroscience and the ways in which researchers examine the relationship between the mind and the brain.

Requisite: PSYC 100 or consent of the instructor. Limited to 40 students. Offered Fall 2022: Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2020, Fall 2020, Fall 2022, Fall 2023

213 Neuroscience: Systems and Behavior

(Offered as PSYC 213 and NEUR 213) This course will examine how brain function regulates a broad range of mental processes and behaviors. We will discuss how neurons work and how the brain obtains information about the environment (sensory systems), regulates an organism’s response to the environment (motor systems), controls basic functions necessary for survival such as eating, drinking, sex, and sleep, and mediates higher cognitive function such as memory and language. We will also consider the consequences of brain malfunction as manifested in various forms of disease and mental illness. Laboratories will include basic neuroanatomy and behavioral experiments. Three class hours and three hours of laboratory per week.

Requisite: BIOL 191 or PSYC 100 or consent of the instructor. Cannot be taken if PSYC 212 has been taken because of substantial overlap between the two courses. Limited to 36 students. Spring semester. Professor Baird.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2019, Spring 2024

214 Neurobiology

(Offered as BIOL 214 and NEUR 214) An introduction to the structure and function of the nervous system, this course explores the basic functions of neurons and synapses as well as neural mechanisms of sensation at molecular, cellular, circuit and system levels. Basic topics in neurobiology and neurophysiology will be covered with emphasis on neuroscience history and understanding how neuroscientists approach the study of the nervous system. Three class hours per week.

Requisite: BIOL 191. Limited to 45 students. Fall and Spring semester. Professors Kim and Roche.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

245 Systems Neuroscience

The course will survey behavioral neurobiological systems. Students will explore recent research findings in areas pertaining to the role of neural circuits in several behavioral processes including but not limited to echolocation, mating, prey location, flight control, spatial navigation, song development in birds, mineral appetites, social functions, aggression, and learning and memory mechanisms in several species. Through instructor supervision, discussion, group presentations, and peer review, each student develops a specific research project that results in a research proposal. The course will place significant emphasis on the development of writing skills. Key goals of the course are to prepare juniors for upper-level seminars and to provide an intensive literature-research and writing experience. This course will count as a Group A/List A elective course for the neuroscience major.

Limited to juniors and seniors who have taken NEUR 226 or NEUR 213/214 or consent of the instructor. Limited to 18 students. Fall semester. Professor Baird.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022

301 Molecular Neurobiology with Lab

(Offered as BIOL 301 and NEUR 301) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain and synapse development as well as neuronal death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will supplement the lectures and also emphasize current molecular techniques utilized in the study of the nervous system. Four classroom hours and three hours of laboratory per week.

While enrolled at the college, students may only take either BIOL/NEUR-301 or BIOL/NEUR-303.

Requisite: Bio 191. Bio/Neur 214 strongly suggested.

Limited to 18 students. Spring semester. Professor Roche.

2022-23: Not offered
Other years: Offered in Fall 2011, Fall 2014, Fall 2015, Fall 2016, Spring 2020, Spring 2021, Spring 2022, Fall 2023

303 Molecular Neurobiology: CURE

(Offered as BIOL 303 and NEUR 303) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain development, from neurogenesis, neurite growth, and synaptogenesis to cell death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will emphasize current molecular techniques utilized in the study of the nervous system. This course is a CURE, a Course-based Undergraduate Research Experience. Students will engage in scientific practice, make novel discoveries, participate in iterative work and collaborate with peers. The goal is to give students an authentic research experience in which they will acquire necessary skills for being a scientist. Four classroom hours and three hours of laboratory per week.

Requisite: BIOL 214 or BIOL 260. Limited to 18 students. Spring semester. Professor Kim.

2022-23: Offered in Spring 2023

317 Neurobiology of Appetite

Although the ingestive act per se is clear and simple, understanding the multifarious influences that are distilled into the decision at any given moment to eat, or not to eat, remains a ponderous challenge for scientists. The obesity epidemic of the last several decades continues to spread across the globe, leading to a rise in metabolic diseases and more pressing need than ever to understand the neurobiological controls of eating and body weight. Through a broad survey of neurobiological research literature, we will explore how various neurobiological systems and behavioral processes influence eating and body weight, including metabolism, neural mechanisms of hunger and satiety, metabolic disorders, dieting, pica, failure to thrive, starvation, taste preference and aversion, obesity, anxiety and depression, food taboos, and all eating disorders. Strong emphasis will be placed on biological mechanisms and controlled laboratory research with both human and animal subjects.

Limited to 20 students. Open to juniors and seniors. Fall semester. Prof. Baird.  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Fall 2023

325 Psychopharmacology

(Offered as PSYC 325 and NEUR 325) In this course we will examine the ways in which drugs act on the brain to alter behavior. We will review basic principles of brain function and mechanisms of drug action in the brain. We will discuss a variety of legal and illegal recreational drugs as well as the use of psychotherapeutic drugs to treat mental illness. Examples from the primary scientific literature will demonstrate the various methods used to investigate mechanisms of drug action, the biological and behavioral consequences of drug use, and the nature of efforts to prevent or treat drug abuse.

Requisite: PSYC 212/NEUR 213, or consent of the instructor. Limited to 18 students. Not open to five college students. Spring semester. Professor Turgeon.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Spring 2018, Spring 2019, Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

351 Neurophysiology with Lab

(Offered as BIOL 351 and NEUR 351) This laboratory course will provide a deeper understanding of the physiological properties of the nervous system. We will address the mechanisms underlying electrical activity in neurons, as well as examine the physiology of synapses; the transduction and integration of sensory information; the function of nerve circuits; the trophic and plastic properties of neurons; and the relationship between neuronal activity and behavior. Laboratories will apply electrophysiological methods to examine neuronal activity and will include experimental design as well as analysis and presentation of collected data. Throughout the course, we will focus on past and current neurophysiology research and how it contributes to the field of neuroscience. Three hours of laboratory work per week.

Requisites: BIOL 191 and CHEM 151; PHYS 117 or 124 is recommended. Limited to one lab section with 18 students. Open to juniors and seniors. Fall semester. Professor Trapani.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2012, Fall 2013, Fall 2016, Fall 2022

361 Consciousness and the Brain

(Offered as PSYC 361 and NEUR 361) Although curiosity about the nature of consciousness has animated the work of philosophers, artists and others, this course will approach the topic from a scientific perspective. How do electrochemical signals in our brain produce our experience of colors, sounds, tastes and our awareness of ourselves? We will read and discuss primary source scientific journal articles drawn from both psychology and neuroscience with a focus on questions including: What kinds of brain activity distinguish conscious from unconscious states? Can objects in the environment (e.g., advertisements) affect our behavior even if we are not consciously aware of those objects? Are there different types of consciousness? Is consciousness peculiar to human beings (does it require language?) or is consciousness experienced by other species, as well? Does science have the tools necessary to achieve a complete understanding of human consciousness? Overall, the goal of this course is to provide students with a thorough understanding of the current states of the scientific study of consciousness.

Requisite: PSYC 211, PSYC 212, PSYC 233, or PSYC/NEUR 213. Limited to 18 students. Offered Fall semester. Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2018, Fall 2019, Spring 2021, Fall 2022, Fall 2023

367 Human Neuroscience

(Offered as PSYC 367 and NEUR 367) This course will be an in-depth exploration of contemporary issues in the field of human neuroscience. Topics include a rigorous examination of the methods neuroscientists use to study the human brain, how the brain changes throughout the lifespan, the ways in which researchers have developed brain/machine interfaces, and the neural processes that support decision-making. For each topic, we will read several empirical articles and discuss them with an emphasis on experimental design, factors that may be confounding the data, and interpretation of the data. Assignments will include weekly response papers, an oral presentation, in-class debates, and a research proposal. Overall, the goal of this course is for students to gain an understanding of the cutting edge of human neuroscience research and to increase their ability to think like scientists.

Requisite: PSYC 211 or PSYC 212 or PSYC/NEUR 213 or consent of the instructor. Limited to 18 students. Offered spring semester. Professor Cohen.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2020, Spring 2021, Spring 2024

390 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2007, Fall 2008, Fall 2009, Fall 2010, Fall 2011, Fall 2022

391 Quantitative Imaging with Lab: From Molecules to Cells and Beyond

(Offered as BIOL 391, BCBP 391, and NEUR-391) Fluorescence imaging offers a window to understanding the structure and function of living cells at sub-cellular resolution. This laboratory and lecture course will focus on advanced quantitative fluorescence microscopy techniques used for imaging a range of biological model systems and functions ranging from single molecules to cells to tissues. Students will learn the fundamentals of optics and microscopy and gain hands-on experience with classical and emerging imaging technology including: confocal microscopy, deconvolution and super-resolution methods, and live-cell imaging. Fluorescent probes and genetically encoded biosensors will be discussed and used to study dynamic cellular processes. In addition, the class will explore a range of image processing and analysis workflows. Lectures dealing with the theory, mechanics, and application of fluorescent imaging methods will be intermingled with extended laboratory sessions in our new Amherst Biological Imaging Center.

Pre requisites : BIOL 191 and PHYS 117 and one of BIOL/BCBP291, BIOL221 or BIOL/NEUR 301, or with instructor permission.

There will be two 80-minute lectures and a weekly laboratory. Limited to 12 students. Fall semester. Professors Edwards and Kim  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Spring 2024

450 Seminar in Physiology: Classic Papers in Neurophysiology

(Offered as BIOL 450 and NEUR 450) Concentrating on reading and interpreting primary research, this course will focus on classic and soon-to-be classic neurophysiology papers. We will discuss the seminal experiments performed in the 1950s that led to our understanding of action potentials; experiments in the 1960s and 1970s that unlocked how synapses function; and more recent research that combines electrophysiology with optical methods and genetic techniques to investigate the role of many of the molecular components predicted by the work from the earlier decades. Assignments will include written reviews of literature as well as oral presentations.

Requisite: PHYS 117 or PHYS 124 and one of BIOL-214, BIOL 260, BIOL 350/351, or consent of the instructor. Limited to 18 students. Not open to first-year students. Spring Semester. Professor Trapani.

2022-23: Not offered
Other years: Offered in Spring 2013, Spring 2017, Spring 2019, Spring 2022, Spring 2024

490 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2013, Spring 2014, Fall 2014, Spring 2015, Fall 2015, Spring 2016, Fall 2016, Spring 2017, Fall 2017, Spring 2018, Fall 2018, Spring 2019, Fall 2019, Spring 2020, Fall 2020, Spring 2021, Fall 2021, Spring 2022, Fall 2022

498, 498D, 499, 499D Senior Departmental Honors

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research.

Fall semester. The Committee.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Fall 2017, Fall 2018, Fall 2019, Fall 2020, January 2021, Fall 2021, Fall 2022, Fall 2023
Department Website

Honors & Fellowships

Back

Neuroscience

Neuroscience Advisory Committee: Professors Baird, Cohen, Kim, Trapani, Turgeon (Chair), Visiting Assistant Professor Roche.

Affiliated Faculty: Professors Clotfelter and Goutte.

The Neuroscience major consists of science courses in Biology, Chemistry, Mathematics, Physics, and Psychology, plus senior comprehensives, which includes attending neuroscience seminars and a comprehensive examination. Neuroscience majors may also choose to do a senior honors research project in the laboratory of a Neuroscience faculty member or affiliated Biology faculty member (and in some cases a faculty member from UMass-Amherst). Neuroscience majors must preregister for all courses that they will use to satisfy requirements for the major, rather than assume they will be guaranteed entry into a course during the add/drop period (e.g., you must preregister for NEUR 301 and/or NEUR 351). Courses in which a student has not received a letter grade better than "D" are not counted towards the Neuroscience major.

To receive Advanced Placement (AP) in a neuroscience course, you must have fulfilled the following requirements:

Chemistry: with a Chemistry AP score of 4 or 5, follow the recommendation made during orientation (many students with AP credit still take CHEM 151).Math: you may place out MATH 111 with a score of 4 or 5 on the AB exam or a 3 on the BC exam. In this case, you still need to satisfy the Physics/Mathematics requirement with a higher-level.Biology: you may place out of BIOL 191 with a score of 5 on the Biology AP exam. In this case you must substitute BIOL 251 or BIOL 291 for BIOL 191.

Neuroscience majors must complete the following requirements:

(1) General science requirements:

Chemistry: All of the following:

CHEM 151 (or 155)CHEM 161CHEM 221 (most majors also take CHEM 231)

Biology:

BIOL 191Note: BIOL 181 is optional for Neuroscience, but should be considered by students in their first year that are considering majoring in Biology or Neuroscience but haven't decided between them yet.

Statistics: One of the following:

STAT 111 (formerly MATH 130) orMATH/STAT 135 orSTAT 230 (formerly MATH 230) orBIOL 210 orPSYC 122

Physics/Mathematics: At least two of the following courses:

PHYS 116, 117, 123, 124MATH 111, 121, 211If you have Advanced Placement in any of these subjects, take more advanced courses.MATH 111 or Advanced Placement (at least 4 on AB or 3 on BC) is a prerequisite for CHEM 161 and PHYS 117.The Statistics requirement above is a separate requirement and does not count towards this Physics/Math requirement.

(2) Introduction to Neuroscience course:

Neuroscience Majors must take the following two courses:

NEUR 213: Neuroscience: Systems and Behavior (with lab)NEUR 214: Neurobiology (non lab)Note: The NEUR 213 course must be taken in the spring semester of your sophomore year. The NEUR 214 course may be taken in the fall of either sophomore or junior year but must be completed prior to the end of junior year.

(3) Upper-level Behavioral Neuroscience:

One of the following seminar courses:

NEUR 325 PsychopharmacologyNEUR 356 Neurophysiology of Motivation

(4) Upper-level Cellular/Molecular Neuroscience:

One of the following lab courses:

NEUR 301 Molecular Neurobiology with laboratoryNEUR 351 Neurophysiology with laboratory

(5) Upper-level Human Neuroscience:

Neuroscience Majors must take one of the following courses:

NEUR 361 Consciousness and the BrainNEUR 367 Human Neuroscience

(6) Upper-level Elective:

One additional upper-level elective from the following courses:

An additional behavioral neuroscience course from item (3) aboveAn additional molecular/cellular neuroscience course from item (4) aboveAn additional human neuroscience course from item (5) aboveNEUR 350 Neurophysiology (non-lab section of NEUR 351)NEUR 425 Systems NeuroscienceNEUR 450 Seminar in PhysiologyBIOL 221 Developmental Biology (w/ lab)BIOL 241 Genetic Analysis (w/ lab)BIOL 251 Molecular Genetics (w/ lab)BIOL 260 Animal PhysiologyBIOL 271 Microbiology (w/ lab)BIOL 281 Animal Behavior (w/ lab)BIOL 291 Cell Structure and Function (w/ lab)BIOL 331 Biochemistry (w/ lab)BIOL 381 Genome Biology (w/ lab)BIOL/NEUR 411 Seminar in Synapses: Synaptic Development and PlasticityPSYC 233 Cognitive PsychologyPSYC 234 MemoryPSYC 236 Psychology of AgingPSYC 357 History of Psychiatry

* On leave 2022-23.† On leave fall semester 2022-23. ‡ On leave spring semester 2022-23.

211 Cognitive Neuroscience

(Offered as PSYC 211 and NEUR 211) Historically, psychologists and neuroscientists have worked somewhat in parallel to one another. While psychologists have traditionally focused on how humans think, feel, and behave, neuroscientists have primarily focused exclusively on the workings of the brain. Cognitive neuroscience is a relatively new discipline that lies at the intersection of these fields and seeks to understand the neurobiological processes that underlie cognition. This course serves as a broad introduction to the field of cognitive neuroscience and will focus on a variety of questions, including the following: How does the brain obtain and process information about the environment via sight, taste, and touch? How does the brain support our capacity to learn and speak different languages? What happens to the brain when it is afflicted with neurological disorders such as Alzheimer’s, amnesia, schizophrenia, and autism? This course will provide students with a foundational understanding of modern cognitive neuroscience and the ways in which researchers examine the relationship between the mind and the brain.

Requisite: PSYC 100 or consent of the instructor. Limited to 40 students. Offered Fall 2022: Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2020, Fall 2020, Fall 2022, Fall 2023

213 Neuroscience: Systems and Behavior

(Offered as PSYC 213 and NEUR 213) This course will examine how brain function regulates a broad range of mental processes and behaviors. We will discuss how neurons work and how the brain obtains information about the environment (sensory systems), regulates an organism’s response to the environment (motor systems), controls basic functions necessary for survival such as eating, drinking, sex, and sleep, and mediates higher cognitive function such as memory and language. We will also consider the consequences of brain malfunction as manifested in various forms of disease and mental illness. Laboratories will include basic neuroanatomy and behavioral experiments. Three class hours and three hours of laboratory per week.

Requisite: BIOL 191 or PSYC 100 or consent of the instructor. Cannot be taken if PSYC 212 has been taken because of substantial overlap between the two courses. Limited to 36 students. Spring semester. Professor Baird.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2019, Spring 2024

214 Neurobiology

(Offered as BIOL 214 and NEUR 214) An introduction to the structure and function of the nervous system, this course explores the basic functions of neurons and synapses as well as neural mechanisms of sensation at molecular, cellular, circuit and system levels. Basic topics in neurobiology and neurophysiology will be covered with emphasis on neuroscience history and understanding how neuroscientists approach the study of the nervous system. Three class hours per week.

Requisite: BIOL 191. Limited to 45 students. Fall and Spring semester. Professors Kim and Roche.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

245 Systems Neuroscience

The course will survey behavioral neurobiological systems. Students will explore recent research findings in areas pertaining to the role of neural circuits in several behavioral processes including but not limited to echolocation, mating, prey location, flight control, spatial navigation, song development in birds, mineral appetites, social functions, aggression, and learning and memory mechanisms in several species. Through instructor supervision, discussion, group presentations, and peer review, each student develops a specific research project that results in a research proposal. The course will place significant emphasis on the development of writing skills. Key goals of the course are to prepare juniors for upper-level seminars and to provide an intensive literature-research and writing experience. This course will count as a Group A/List A elective course for the neuroscience major.

Limited to juniors and seniors who have taken NEUR 226 or NEUR 213/214 or consent of the instructor. Limited to 18 students. Fall semester. Professor Baird.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022

301 Molecular Neurobiology with Lab

(Offered as BIOL 301 and NEUR 301) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain and synapse development as well as neuronal death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will supplement the lectures and also emphasize current molecular techniques utilized in the study of the nervous system. Four classroom hours and three hours of laboratory per week.

While enrolled at the college, students may only take either BIOL/NEUR-301 or BIOL/NEUR-303.

Requisite: Bio 191. Bio/Neur 214 strongly suggested.

Limited to 18 students. Spring semester. Professor Roche.

2022-23: Not offered
Other years: Offered in Fall 2011, Fall 2014, Fall 2015, Fall 2016, Spring 2020, Spring 2021, Spring 2022, Fall 2023

303 Molecular Neurobiology: CURE

(Offered as BIOL 303 and NEUR 303) An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. We will also study the molecular mechanisms that control brain development, from neurogenesis, neurite growth, and synaptogenesis to cell death and degeneration. In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. Readings from primary literature will emphasize current molecular techniques utilized in the study of the nervous system. This course is a CURE, a Course-based Undergraduate Research Experience. Students will engage in scientific practice, make novel discoveries, participate in iterative work and collaborate with peers. The goal is to give students an authentic research experience in which they will acquire necessary skills for being a scientist. Four classroom hours and three hours of laboratory per week.

Requisite: BIOL 214 or BIOL 260. Limited to 18 students. Spring semester. Professor Kim.

2022-23: Offered in Spring 2023

317 Neurobiology of Appetite

Although the ingestive act per se is clear and simple, understanding the multifarious influences that are distilled into the decision at any given moment to eat, or not to eat, remains a ponderous challenge for scientists. The obesity epidemic of the last several decades continues to spread across the globe, leading to a rise in metabolic diseases and more pressing need than ever to understand the neurobiological controls of eating and body weight. Through a broad survey of neurobiological research literature, we will explore how various neurobiological systems and behavioral processes influence eating and body weight, including metabolism, neural mechanisms of hunger and satiety, metabolic disorders, dieting, pica, failure to thrive, starvation, taste preference and aversion, obesity, anxiety and depression, food taboos, and all eating disorders. Strong emphasis will be placed on biological mechanisms and controlled laboratory research with both human and animal subjects.

Limited to 20 students. Open to juniors and seniors. Fall semester. Prof. Baird.  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Fall 2023

325 Psychopharmacology

(Offered as PSYC 325 and NEUR 325) In this course we will examine the ways in which drugs act on the brain to alter behavior. We will review basic principles of brain function and mechanisms of drug action in the brain. We will discuss a variety of legal and illegal recreational drugs as well as the use of psychotherapeutic drugs to treat mental illness. Examples from the primary scientific literature will demonstrate the various methods used to investigate mechanisms of drug action, the biological and behavioral consequences of drug use, and the nature of efforts to prevent or treat drug abuse.

Requisite: PSYC 212/NEUR 213, or consent of the instructor. Limited to 18 students. Not open to five college students. Spring semester. Professor Turgeon.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Spring 2018, Spring 2019, Fall 2019, Fall 2020, Fall 2021, Fall 2022, Fall 2023

351 Neurophysiology with Lab

(Offered as BIOL 351 and NEUR 351) This laboratory course will provide a deeper understanding of the physiological properties of the nervous system. We will address the mechanisms underlying electrical activity in neurons, as well as examine the physiology of synapses; the transduction and integration of sensory information; the function of nerve circuits; the trophic and plastic properties of neurons; and the relationship between neuronal activity and behavior. Laboratories will apply electrophysiological methods to examine neuronal activity and will include experimental design as well as analysis and presentation of collected data. Throughout the course, we will focus on past and current neurophysiology research and how it contributes to the field of neuroscience. Three hours of laboratory work per week.

Requisites: BIOL 191 and CHEM 151; PHYS 117 or 124 is recommended. Limited to one lab section with 18 students. Open to juniors and seniors. Fall semester. Professor Trapani.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2012, Fall 2013, Fall 2016, Fall 2022

361 Consciousness and the Brain

(Offered as PSYC 361 and NEUR 361) Although curiosity about the nature of consciousness has animated the work of philosophers, artists and others, this course will approach the topic from a scientific perspective. How do electrochemical signals in our brain produce our experience of colors, sounds, tastes and our awareness of ourselves? We will read and discuss primary source scientific journal articles drawn from both psychology and neuroscience with a focus on questions including: What kinds of brain activity distinguish conscious from unconscious states? Can objects in the environment (e.g., advertisements) affect our behavior even if we are not consciously aware of those objects? Are there different types of consciousness? Is consciousness peculiar to human beings (does it require language?) or is consciousness experienced by other species, as well? Does science have the tools necessary to achieve a complete understanding of human consciousness? Overall, the goal of this course is to provide students with a thorough understanding of the current states of the scientific study of consciousness.

Requisite: PSYC 211, PSYC 212, PSYC 233, or PSYC/NEUR 213. Limited to 18 students. Offered Fall semester. Professor Cohen.

2022-23: Offered in Fall 2022
Other years: Offered in Spring 2018, Fall 2019, Spring 2021, Fall 2022, Fall 2023

367 Human Neuroscience

(Offered as PSYC 367 and NEUR 367) This course will be an in-depth exploration of contemporary issues in the field of human neuroscience. Topics include a rigorous examination of the methods neuroscientists use to study the human brain, how the brain changes throughout the lifespan, the ways in which researchers have developed brain/machine interfaces, and the neural processes that support decision-making. For each topic, we will read several empirical articles and discuss them with an emphasis on experimental design, factors that may be confounding the data, and interpretation of the data. Assignments will include weekly response papers, an oral presentation, in-class debates, and a research proposal. Overall, the goal of this course is for students to gain an understanding of the cutting edge of human neuroscience research and to increase their ability to think like scientists.

Requisite: PSYC 211 or PSYC 212 or PSYC/NEUR 213 or consent of the instructor. Limited to 18 students. Offered spring semester. Professor Cohen.

2022-23: Offered in Spring 2023
Other years: Offered in Spring 2020, Spring 2021, Spring 2024

390 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2007, Fall 2008, Fall 2009, Fall 2010, Fall 2011, Fall 2022

391 Quantitative Imaging with Lab: From Molecules to Cells and Beyond

(Offered as BIOL 391, BCBP 391, and NEUR-391) Fluorescence imaging offers a window to understanding the structure and function of living cells at sub-cellular resolution. This laboratory and lecture course will focus on advanced quantitative fluorescence microscopy techniques used for imaging a range of biological model systems and functions ranging from single molecules to cells to tissues. Students will learn the fundamentals of optics and microscopy and gain hands-on experience with classical and emerging imaging technology including: confocal microscopy, deconvolution and super-resolution methods, and live-cell imaging. Fluorescent probes and genetically encoded biosensors will be discussed and used to study dynamic cellular processes. In addition, the class will explore a range of image processing and analysis workflows. Lectures dealing with the theory, mechanics, and application of fluorescent imaging methods will be intermingled with extended laboratory sessions in our new Amherst Biological Imaging Center.

Pre requisites : BIOL 191 and PHYS 117 and one of BIOL/BCBP291, BIOL221 or BIOL/NEUR 301, or with instructor permission.

There will be two 80-minute lectures and a weekly laboratory. Limited to 12 students. Fall semester. Professors Edwards and Kim  

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2022, Spring 2024

450 Seminar in Physiology: Classic Papers in Neurophysiology

(Offered as BIOL 450 and NEUR 450) Concentrating on reading and interpreting primary research, this course will focus on classic and soon-to-be classic neurophysiology papers. We will discuss the seminal experiments performed in the 1950s that led to our understanding of action potentials; experiments in the 1960s and 1970s that unlocked how synapses function; and more recent research that combines electrophysiology with optical methods and genetic techniques to investigate the role of many of the molecular components predicted by the work from the earlier decades. Assignments will include written reviews of literature as well as oral presentations.

Requisite: PHYS 117 or PHYS 124 and one of BIOL-214, BIOL 260, BIOL 350/351, or consent of the instructor. Limited to 18 students. Not open to first-year students. Spring Semester. Professor Trapani.

2022-23: Not offered
Other years: Offered in Spring 2013, Spring 2017, Spring 2019, Spring 2022, Spring 2024

490 Special Topics

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research. Full course.

Fall and spring semesters. The Committee.

2022-23: Offered in Fall 2022, Spring 2023
Other years: Offered in Fall 2011, Spring 2012, Fall 2012, Spring 2013, Fall 2013, Spring 2014, Fall 2014, Spring 2015, Fall 2015, Spring 2016, Fall 2016, Spring 2017, Fall 2017, Spring 2018, Fall 2018, Spring 2019, Fall 2019, Spring 2020, Fall 2020, Spring 2021, Fall 2021, Spring 2022, Fall 2022

498, 498D, 499, 499D Senior Departmental Honors

Research in an area relevant to neuroscience, under the direction of a faculty member, and preparation of a thesis based upon the research.

Fall semester. The Committee.

2022-23: Offered in Fall 2022
Other years: Offered in Fall 2011, Fall 2012, Fall 2013, Fall 2014, Fall 2015, Fall 2016, Fall 2017, Fall 2018, Fall 2019, Fall 2020, January 2021, Fall 2021, Fall 2022, Fall 2023
Department Website