Biology

Human PTC Bitter Taste Receptor

1. Kim U, Jorgenson E, Coon H, et al. Positional Cloning of the Human Quantitative Trait Locus Underlying Taste Sensitivity to Phenylthiocarbamide. Science. 2003;299(5610):1221-1225.  

2. Kim UK, Drayna D. Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clinical Genetics. 2004;67(4):275-280.  

3. Wooding S, Kim U, Bamshad MJ, et al. Natural Selection and Molecular Evolution in PTC, a Bitter-Taste Receptor Gene. American Journal of Human Genetics. 2004;74(4):637-646.  

4. Bufe B, Breslin PA, Kuhn C, et al. The Molecular Basis of Individual Differences in Phenylthiocarbamide and Propylthiouracil Bitterness Perception. Current Biology. 2005;15(4):322-327.  

5. Floriano W, Hall S, Vaidehi N, et al. Modeling the human PTC bitter-taste receptor interactions with bitter tastants. Journal of Molecular Modeling. 2006;12(6):931-941.  

6. Wooding S, Bufe B, Grassi C, et al. Independent evolution of bitter-taste sensitivity in humans and chimpanzees. Nature. 2006;440(7086):930-934.  

7. Wooding S. Phenylthiocarbamide: a 75-year adventure in genetics and natural selection. Genetics. 2006;172:2015-2023

8. Lalueza-Fox C, Gigli E, de la Rasilla M, Fortea J, Rosas A. Bitter taste perception in Neanderthals through the analysis of the TAS2R38 gene. Biology Letters. 2009;5(6):809-811.  

 

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