Cell Polarity Oscillations in Mitotic Epithelia
Sophia Doerr'19, Katerina Ragkousi
Current Opinion in Genetics & Development
Issue 57, August 2019

Doerr and Ragkousi 2019 Fig 1.jpg

Epithelial organization and function depend on coordinated cell polarity. In developing tissues, proliferative epithelia maintain whole tissue polarity as individual cells undergo symmetric divisions. However, recent work has shown that cells in diverse epithelia remodel their polarity in a cell cycle-dependent manner. Here, we discuss the different mechanisms that drive mitotic polarity oscillations and their implications for tissue morphogenesis.