Published in The Journal of Biological Chemistry, July 2016

MacDiarmid CW, Taggart J, Jeong J, Kerdsomboon K, and Eide DJ

“Activation of the yeast UBI4 polyubiquitin gene by Zap1 viaan intragenic promoter is critical for zinc-deficient growth”

Stability of many proteins requires zinc. This work highlights the importance of the ubiquitin-proteasome system for protein homeostasis when zinc supplies are inadequate in cells.