HOP-1 Presenilin Deficiency Causes a Late-Onset Notch Signaling Phenotype that Affects Adult Germline Function in C. elegans
Volume 208, February 2018 (Epub Dec 2017)
Ipsita Agarwal’13, Cassandra Farnow’13, Joshua Jiang’17, Kyung-Sik Kim’17, Donna E. Leet’15, Ruth Z. Solomon’16, Valerie A. Hale, Caroline Goutte
Functionally redundant genes offer an interesting opportunity for molecular specialization. Presenilin proteins are known to be essential for mediating Notch signaling, but it is not known why many species, including humans, have two different presenilin genes. Here we discover a unique role for one of the two presenilin genes of C. elegans (HOP-1). We show that HOP-1 is essential for maintaining adult germline function, a role that is not shared by its paralog, the SEL-12 presenilin.
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