Biology Research News Archives

This page archives older entries featured on the Research News page.  The Research News page highlights recent and ongoing research by Amherst College's faculty and students in Biology.


 

Poccia Lab: Principle of Duality in Phospholipids: Regulators of Membrane Morphology and Dynamics

Larijani, B., Hamati, F.14, Kundu, A.13, Chung, G., Domart, M.-C., Collinson, L. and Poccia, D.

2014 Biochem Soc Transactions  42: 1335-1342

Poccia_Duality_Image_1.jpg To suggest and develop intelligent strategies to comprehend the regulation of organelle formation, a deeper mechanistic interpretation requires more than just the involvement of proteins. Our findings have led to the demonstration of a structural role for phosphoinositides and their derivatives in nuclear membrane formation.

 

 

 

 

Poccia 2014 Duality Image.jpg We also show that phosphoinositides and their derivatives, as well as acting as second messengers, are modulators of membrane morphology and organelle shaping. Development of quantitative image analysis of echinoderm egg endoplasmic reticulum permits direct comparison of effects of phospholipid alteration on organelle shape.

Poccia Lab: Quantification of exocytosis kinetics by DIC image analysis of cortical lawns

James Mooney’12E, Saumitra Thakur’11, Peter Kahng’13, Josef G. Trapani & Dominic Poccia

J. Chemical Biology 7 :43-55 (2014)

Poccia_Quantification_Image_1.jpg Poccia_Quantification_Image_2.jpg Rapid image acquisition reveals spatial variations in time of initiation of exocytosis of individual cortical granules.

 

occia_Quantification_Image_3.jpg

Clotfelter Lab: "Guanine-Based Structural Coloration as an Indicator of Oxidative Stress in a Cichlid Fish"

In Press

Clotfelter_Pic2

Matthew D. Cahn ‘13, Alexandria C. Brown and Ethan D. Clotfelter. Guanine-based structural coloration as an indicator of oxidative stress in a cichlid fish. Journal of Experimental Zoology, in press.

 "We used a novel approach to measure structural coloration in a fish and found that structural coloration can be condition-dependent and indicative of environmental stress."

Clotfelter_Pic1


Uploaded:
10 Nov 2015 KAR

 

Hood Lab: Variation in mate-recognition pheromones of the fungal genus Microbotryum

Recent Publication

Lucy Xu, Elsa Petit, Michael E. Hood. HEREDITY August 2015:online early doi: 10.1038/hdy.2015.68

Fungi often recognize mating partners by the reciprocal exchange of pheromones.

We show that reciprocal pheromones & receptors can co-evolve at different rates. Different rates of co-evolution might reflect the contrasting roles of mating types during the conjugation process, as initiators versus responders


 

Purdy Lab: “The Acetate Switch of an Intestinal Pathogen Disrupts Insulin Signaling and Lipid Metabolism"

Recent Publication

Purdy Research Photo Saiyu Hang, Alexandra E. Purdy, William P. Robins, Zhipeng Wang, Manabendra Mandal, Sarah Chang, John J. Mekalanos, and Paula I. Watnick. The acetate switch of an intestinal pathogen disrupts insulin signaling and lipid metabolism. Cell Host & Microbe. November 12, 2014.

Vibrio cholerae unexpectedly manipulates host metabolism and virulence by controlling acetate levels in the GI tract via the CrbRS signal transduction system.


Published:
30 Jan 2015 TLR

Hood Lab: Chaos of rearrangements in the mating-type chromosomes of the anther-smut fungus Microbotryum lychnidis-dioicae

Recent Publication

Badouin*, H., Hood*, M.E., Gouzy, J., Aguileta, G., Siguenza, S., Perlin, M.H., Cuomo, C.A., Branca, A., and Giraud, T. (* co-first authors). Chaos of rearrangements in the mating-type chromosomes of the anther-smut fungus Microbotryum lychnidis-dioicae. Genetics (2015) online early DOI: 10.1534/genetics.115.177709.

Genomic regions linked to mating compatibility factors are rich in repetitive DNA and notoriously difficult to study.  We used the PacBio sequencing technology to completely assemble fungal mating type chromosomes.

Rearrangements of an unprecedented scale were found, supporting the very ancient nature of the mating-type chromosomes, which rivals the dynamics seen in mammalian XX/XY sex  chromosomes.

Hood Lab


Hood Lab: "Degeneration of the Non-Recombining Regions in the Mating-Type Chromosomes of the Anther-Smut Fungi"

Recent Publication

Fontanillas E, Hood ME,  Badouin H Petit E,  Barbe V, Gouzy J,  de Vienne DM, Aguileta G, Poulain J, Wincker P, Chen Z, Toh SS, Cuomo CA, Perlin MH, Gladieux P, Giraud T.  Degeneration of the non-recombining regions in the mating-type chromosomes of the anther-smut fungi.  Molecular Biology and Evolution (2015) 32: 928-943.

Genes for mating compatibility often reside in regions of suppression recombination and cytological differentiation within the chromosome pair.

Hood_Picture.png


Uploaded:
3 April 2015 TLR

Hood Lab: "Rate of Resistance Evolution and Polymorphism in Long- and Short-Lived Hosts"

Recent Publication

Emme Bruns, Michael E. Hood, and Janis Antonovics. Rate of resistance evolution and polymorphism in long- and short-lived hosts. Evolution DOI:10.1111/evo.12577, Vol 69, 2015.

Conventional wisdom suggests that long-live species are slow to evolve, but with infectious diseases, host lifespan correlates with more rapid fixation of resistance.

Hood Research Photo


Published:
30 Jan 2015 TLR

Miller Lab: "Intraspecific Variation in Gender Strategies"

Recent Publication

Caitlin M. Blank'14, Rachel A. Levin, and Jill S. Miller. "Intraspecific variation in gender strategies: associations with ploidy and changes in floral form following the evolution of gender dimorphism." American Journal of Botany, Vol. 101, December 2014.

A study of a species with polymorphism in sexuality and ploidy reveals the convergent evolution of separate sexes in some diploid populations in Hawaii and in tetraploid populations in Mexico.  Changes in flower size and shape are reconstructed following transitions from hermaphroditism to separate sexes.

Miller Research Photo


 Published:
30 Jan 2015 TLR