Date

Prof

Lab

Topic

Reading

                     Introduction     

Jan.25

SG

ST

No lab this week

Introduction to neuroscience

Chapter 1

27

SG

Approaches to studying brain and behavior

Chapter 2

                  Development of the nervous system

29

 

SG

Neurohistology

Neurogenesis, migration

Chap. 7 (178-195); 23 (690-8)

Feb. 1

Axon pathfinding; cell death

Chapter 23 (698-708)

3

Role of neural activity in development

Hua JY, Smear MC, Baier H, Smith SJ.  Regulation of axon growth in vivo by activity-based competition. Nature 434 (2005) 1022-1026

                 Electrical signaling

5

 

SG

Electrophysiology    

Membranes & membrane potentials

 

Chapter 3

8

Action potential

Chapter 4

10

Conductance mechanisms

Stringer JL.  Regulation of extracellular potassium in the developing hippocampus. Developmental Brain Research 110 (1998) 97‑103. 

12

 
ST

Outline of neuroanatomy

 Chapter 7 (168-180; 193-199; 205-216; 227-235); Chapter 15 (490-498)

                  Synaptic transmission

15

 

SG

Neuroanatomy I

 

Chemical and electrical transmission

Chapter 5 (102-122)

17

Postsynaptic potentials; neural   integration

Chapter 5 (122-131)

19

ST

Neurotransmitter systems

Chapter 6; Chapter 15 (498-507)

22

 

ST

Neuroanatomy II

Neurotransmitter systems (Cont,)
Castner SA, Xiao L, Becker JB. Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies.   Brain Research 610 (1993) 127-134.

24

Morgan DG et al. Divergent changes in D-1 and D-2 dopamine binding sites in human   brain during aging.   Neurobiology of Aging 8 (1987) 95-201.

 

25/26

Exam 1

                 Sensory neuroscience

Mar.1

 

SG

 

Neuroanatomy III

Vision: transduction; receptive fields

Chapter 9 (288-306)

3

Visual information processing

Chapter 10 (310-329)

5

Visual cortex functions                                Chapter 10 (330-341)

Ferster D, Chung S, Wheat H. Orientation selectivity of thalamic input to simple cells of cat visual cortex. Nature 380 (1996) 249‑52.

 

8

 

SG

Lab practicals

Visual plasticity; critical periods

Chapter 23 (708-716)

10

Somatosensory system

Chapter 12 (388-408)

12

Pain                                                               Chapter 12 (408-421)

Eisenberger NI, Lieberman MD, Williams KD. Does rejection hurt? An FMRI study of social exclusion.  Science 302 (2003) 290‑292.

             [Spring break] 

22

 

 

ST

Electrophysiology II

Chemoreception                                           Chapter 8

Stratford JM, Curtis KS, Contreras RJ Chorda tympani nerve transaction alters linoleic acid taste discrimination by male and female rats. Physiology and Behavior 89 (2006) 311-319.

24

Auditory system I

Chapter 11 (344-375)

26

 Auditory system II

Zhang H, Cai R, Zhang J, Pan Y, Sun X  Environmental enrichment enhances directional sensitivity of primary auditory cortical neurons in rats. Neurosci. Letters 463 (2009) 162-165.

                 Sensorimotor control systems  

    29

 

ST

Electrophysiology III

Spinal mechanisms 

 Chapter 13

 

      31

Brain mechanisms                                          Chapter 14

Perese DA, Ulman J, Viola J, Ewing SE, Bankiewicz KS. A 6-hydroxy-dopamine-induced selective parkinsonian rat model.  Brain Research 494 (1989) 285-293.

Apr. 1/ 2

Exam 2

                          Neural basis of behavioral plasticity    

5

 

SG

6OHDA surgery

Human and animal memory

Chapter 24

7

Cellular mechanisms of neural plasticity

Chapter 23 (716-722); Chap. 25

9

 

Does LTP underlie human and animal memory?

Hu H, Real E, Takamiya K, Kang M, Ledoux J, Huganir RL and Malinow R. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking, Cell 131 (2007) 160–173.

                Neuroendocrinology, Motivation, and Stress

12

JPB

 6OHDA Lesions

Feeding behavior

Chapter 16 (510-531)

14

ST

Endocrine systems        

Chapter 15 (482-490)

16

Sexual behavior                  Chapter 17 (541-561)

Patisaul HB, Fortino AE, Polston EK. Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV.  Neuro-toxicology and Teratology 28 (2006) 111-118.

19

 

ST

Behavior /c-fos

Stress I

Chap. 15 (491-496); 18 (573-582); 22 (668-670)

21

Stress II

Yaka R et al.  Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats.   Behavioural Brain Res. 179 (2007) 126-132.

22/23

Exam 3

                Diseases of the nervous system     

26

 

 

ST

HPLC

 Addiction  

Cruz FC, Marin MT, Planeta CS.  The reinstatement of amphetamine-induced place preference is long-lasting and related to decreased expression of AMPA receptors in the nucleus accumbens.  Neuroscience 151 (2008) 313-319.  

28

 

Depression                           Chapter 22 (673-678)

Hattori, S., et al.  Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi.  Behavioural Brain Res.  180 (2007) 69-76.

30

RF

Neurodegenerative diseases: Huntington’s and ALS

Guest lecture by Dr. Robert Ferrante, Jr.

3

 

ST

Data dicussion

 

Schizophrenia           Chapter 22 (678-685)

Flagstad P, Glenthoj BY, Didriksen M.  Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia.  Neuropsychopharmacology 30 (2005) 250-260.

5

 

 SG

Alzheimer disease               Box 2.3 p. 36-37

Verret L, Jankowsky JL (’91), Xu GM, Borchelt DR, Rampon C..  Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Journal of Neuroscience 27 (2007) 6771-6780.

    7 

 

Review/catchup day