Course outline - pdf





Date

Prof

Lab

Topic

Reading

                              Introduction; Development of the nervous system

Jan.24

JPB/SG

Histology

Introduction to neuroscience

Chapters 1 and 2

26

SG

Neurogenesis, migration

Chapter 7 (178-195); 23 (690-8)

28

Axon pathfinding; cell death 

Chapter 23 (698-708)

31

Electrophysiology I

Role of neural activity in development
Hua JY, Smear MC, Baier H, Smith SJ.  Regulation of axon growth in vivo by activity-based competition. Nature 434 (2005) 1022-1026

 

      Electrical signaling

Feb. 2

Membrane potentials

Chapter 3

4

Action potential

Chapter 4

7

Electrophysiology II

Conductance mechanisms
Stringer JL.  Regulation of extracellular potassium in the developing hippocampus. Developmental Brain Research 110 (1998) 97‑103.

9

JPB

Outline of neuroanatomy

Chap. 7 (168-180; 193-199; 205-216; 227-235); Chap. 15 (490-498) 

 

 

      Synaptic transmission

11

SG

Chemical transmission

Chapter 5 (102-122)

14

Neuroanatomy I

Postsynaptic potentials

Chapter 5 (122-131)

16

Neural integration
Lin S, Ainsworth A, Okada M, Kelsch W, Lois C . Genetically Increased cell-intrinsic excitability enhances neuronal integration into adult brain circuits. Neuron 65 (2010) 32-39.

17/18

 

Exam 1

21

JPB

Neuroanatomy II

Neurotransmitter systems

Chapter 6; Chapter 15 (498-507)

23

Quarta D, Valerio E, Hutcheson DM, Hedou G, Heidbreder C. The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization. Neurocheistry International 56(1) (2010) 11-5.

25

Pilotte NS, Sharpe LG, Kuhar MJ. Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in the nucleus accumbens of Lewis rats.
J. Pharmacology and Experimental Therapeutics 269 (1994) 963‑9.


                                                Sensorimotor systems

28

JPB

Neuroanatomy III

Chemoreception                                      Chapter 8 (252-264)
Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS.  The receptors for mammalian sweet and umami taste. Cell 115 (2003) 255‑66.

Mar. 2

Auditory system I

Chapter 11 (344-375)

4

Auditory system II
Macias, S, Mora EC, Kossi, M, Abel, C, Foeller, E. The auditory cortex of the bat Molossus molossus: Disproportionate search call frequency representation. Hearing Research 250 (2009) 19-26.

7

Lab Practical

Motor systems: spinal

Chapter 13

9

Motor systems: brain                             Chapter 14
Cohen AD, Tillerson JL, Smith AD, Schallert T, Zigmond MJ. Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats: possible role of GDNF.
 J Neurochem. 85(2) (2003) 299-305.

11

SG

Visual system: retina

Chapter 9 (288-306)

                                                   Spring break 

21

SG

Surgery demo

Visual information processing

Chapter 10 (310-329)

23

Visual cortex functions                         Chapter 10 (330-341)
Ferster D, Chung S, Wheat H. Orientation selectivity of thalamic input to simple cells of cat visual cortex. Nature 380 (1996) 249‑52.

24/25

Exam 2

28

6OHDA lesions

Visual system plasticity

Chapter 23 (708-716)

30

Somatosensory system

Chapter 12 (388-408)

Apr.1

Pain                                                         Chapter 12 (408-421)
Eisenberger NI, Lieberman MD, Williams KD. Does rejection hurt? An FMRI study of social exclusion.  Science 302 (2003) 290‑292.

                                          Motivation / Endocrine systems/ Memory

4

JPB

Behavior/cfos

Feeding behavior I 

Chapter 16 (510-522)

6

Feeding behavior II

Chapter 16 (522-531)

8

Endocrine systems

Chapter 15 (482-490)

11

HPLC

Stress

Chapter 15 (491-496); 18(573-582); 22 (668-670)

13

ST*

Sexual behavior

Chapter 17 (541-561)

15

SG

Human and animal memory

Chapter 24

18

Data discussion

Neural plasticity: mechanisms

Chap. 23 (716-722); Chap. 25

20

Does LTP underlie human and animal memory?             
Rogan MT, Stäubli U, Ledoux JE. Fear conditioning induces associative long‑term potentiation in the amygdala.   Nature 390 (1997) 604‑607.

21/22

 

Exam 3

25

JPB

 No lab

Brain mechanisms of reward & addiction  Chapter 16 (522-27)
Reynolds, SM and Berridge KC. Positive and Negative Motivation in Nucleus Accumbens Shell: Bivalent Rostrocaudal Gradients for GABA-Elicited Eating, Taste Liking" / "Disliking" Reactions, Place Preference/Avoidance, and Fear."
J. Neuroscience 22(16) (2002): 7308-7320.

27

Reward & addiction II
Fiorillo, CD, Tobler PN, and Schultz W. "Discrete Coding of Reward Probability and Uncertainty by Dopamine Neurons."
Science 299(5614) (2003): 1898-1902.

 

    Diseases of the nervous system

29

Depression                                                            Chapter 22 (673-678)
Mague SD et al. Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats.
J. Pharmacology and Experimental Therapeutics 305 (2003) 323-330.

May 2

Angiotensin: thirst

Schizophrenia

Chapter 22 (678-685)

4

SG

Neurodegenerative diseases

6

 

Alzheimer disease

Box 2.3 p. 36-37

Pick up May 6 - 10

Final Exam: 3-day take-home

*Guest lecturer, April 13: Prof. Sarah Turgeon 

 

Taking Notes