Final Project and Paper
For your final project and paper: Select a topic that interests you. You can work individually or in a group. You will present your research in class and in writing, in a format to be determined. The following is a partial list of references you can draw from. Most of them are available at the main desk of the Science Library, on the table to the left just after you enter. Feel free to discuss your research with us. Details will follow.
Partial List of References for Clinical Dimensions Part of Biochemical Principles 330
Chen Z-Y, Jing D, Bath KG, Ieraci A, Khan T, et al. 2006. Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314:140-3
Du J, McEwen BS, Manji HK. 2009a. Glucocorticoid receptors modulate mitochondrial function. Commun. & Integr. Biol. 2:1-3
Du J, Wang Y, Hunter R, Wei Y, Blumenthal R, et al. 2009b. Dynamic regulation of mitochondrial function by glucocorticoids. Proc. Natl. Acad. Sci. USA 106:3543-8
Francis D, Diorio J, Liu D, Meaney MJ. 1999. Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 286:1155-8
Gianaros PJ, Horenstein JA, Hariri AR, Sheu LK, Manuck SB, et al. 2008. Potential neural embedding of parental social standing. Soc Cogn Affect Neurosci 3:91-6
Hill MN, Karatsoreos IN, Hillard CJ, McEwen BS. 2010. Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo. Psychoneuroendocrinology 35:1333-8
Hill MN, McEwen BS. 2009. Endocannabinoids: The silent partner of glucocorticoids in the synapse. Proc. Natl. Acad. Sci. USA 106:4579-80
Hunter RG, Bellani R, Bloss E, costa A, Romeo RD, McEwen BS. 2007. Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala. Brain Res. 1152:234-40
Joels M. 2006. Corticosteroid effects in the brain: U-shape it. Trends Pharmacol. Sci. 27:244-50
Joels M, Pu Z, Wiegert O, Oitzl MS, Krugers HJ. 2006. Learning under stress: how does it work? Trends Cogn. Sci.
Johnson LR, Farb C, Morrison JH, McEwen BS, LeDoux JE. 2005. Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala. Neuroscience 136:289-99
Karst H, Berger S, Turiault M, Tronche F, Schutz G, Joels M. 2005. Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc. Natl. Acad. Sci. USA 102:19204-7
Kaufman D, Banerji MA, Shorman I, Smith ELP, Coplan JD, et al. 2007. Early-life stress and the development of obesity and insulin resistance in juvenile bonnet macaques. Diabetes 56:1-5
Kaufman D, Smith ELP, Gohil BC, Banerji MA, Coplan JD, et al. 2005. Early appearance of the metabolic syndrome in socially reared bonnet macaques. J. Clin. Endocrin. & Metab. 90:404-8
Maccari S, Morley-Fletcher S. 2007. Effects of prenatal restraint stress on the hypothalamus-pituitary-adrenal axis and related behavioural and neurobiological alterations. Psychoneuroendo. 32:S10-S5
Moutsatsou P, Psarra A-MG, Tsiapara A, Paraskevakou H, Davaris P, Sekeris CE. 2001. Localization of the glucocorticoid receptor in rat brain mitochondria. Arch. Biochem. Biophys. 386:69-78
Munhoz CD, Sorrells SF, Caso JR, Scavone C, Sapolsky RM. 2010. Glucocorticoids exacerbate lipopolysaccharide-induced signaling in the frontal cortex and hippocampus in a dose-dependent manner. J Neurosci 30:13690-8
Okuda S, Roozendaal B, McGaugh JL. 2004. Glucocorticoid effects on object recognition memory require training-associated emotional arousal. Proc. Natl. Acad. Sci. USA 101:853-8
Poulton R, Caspi A, Milne BJ, Thomson WM, Taylor A, et al. 2002. Association between children's experience of socioeconomic disadvantage and adult health: a life-course study. The Lancet 360:1640-5
Prager EM, Johnson LR. 2009. Stress at the synapse: signal transduction mechanisms of adrenal steroids at neuronal membranes. Sci Signal 2:re5
Quan N, Avitsur R, Stark JL, He L, Lai W, et al. 2003. Molecular mechanisms of glucocorticoid resistance in splenocytes of socially stressed male mice. J. Neuroimmunol. 137:51-8
Sapolsky RM, Romero LM, Munck AU. 2000. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocrine Rev. 21:55-89
Soliman F, Glatt CE, Bath KG, Levita L, Jones RM, et al. 2010. A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science 327:863-6
Tasker JG, Di S, Malcher-Lopes R. 2006. Minireview: Rapid glucocorticoid signaling via membrane-associated receptors. Endocrinology 147:5549-56
Tottenham N, Hare TA, Quinn BT, McCarry TW, Nurse M, et al. 2010. Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulation. Dev Sci 13:46-61
Venero C, Borrell J. 1999. Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats. Eur. J. Neurosci. 1:2465-73
Wakschlak A, Weinstock M. 1990. Neonatal handling reverses behavioral abnormalities induced in rats by prenatal stress. Physiol. Behav. 48:289-92
McEwen BS. Protective and damaging effects of stress mediators. N Engl
J Med. 1998;338:171-179.
Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence
stress responses? Integrating permissive, suppressive, stimulatory, and
preparative actions. Endocr Rev. 2000;21:55-89.
Hariri AR, Goldberg TE, Mattay VS, et al. Brain-derived neurotrophic factor
val66 met polymorphism affects human memory-related hippocampal
activity and predicts memory performance. J Neurosci. 2003;23:6690-6694.
McEwen BS. Protective and damaging effects of stress mediators.
N Engl J Med 338: 171–179, 1998.
McEwen BS. Stress and hippocampal plasticity. Annu Rev Neurosci
22: 105–122, 1999.
McEwen BS, Wingfield JC. The concept of allostasis in biology
and biomedicine. Horm Behav 43: 2–15, 2003
Jack P. Shonkoff, W. Thomas Boyce, Bruce S. McEwen. Neuroscience, Molecular Biology, and the Childhood Roots of Health Disparities: Building a New Framework for Health Promotion and Disease Prevention. JAMA. 2009;301(21):2252-2259
Barker DJ. The fetal and infant origins of adult
disease. BMJ. 1990;301(6761):1111.
Anda RF, Felitti VJ, Bremner JD, et al. The enduring
effects of abuse and related adverse experiences in childhood: a convergence of evidence from neurobiology and epidemiology. Eur Arch Psychiatry Clin
Hillis SD, Anda RF, Dube SR, Felitti VJ, Marchbanks
PA, Marks JS. The association between adverse childhood
experiences and adolescent pregnancy, longterm
psychosocial consequences, and fetal death.
Geronimus AT, Hicken M, Keene D, Bound J.
“Weathering” and age patterns of allostatic load scores
among blacks and whites in the United States. Am J
Public Health. 2006;96(5):826-833.
Cacioppo, J Genome Biology(Vol 8 No R189)and Proceedings of the National Academy of Sciences (PNAS Vol. 108, No. 7): gene activity, immune systems and loneliness
Miller, G. Cole, S. immune systems and SES
Lutgendorf, S social circumstances and gene expression in cancer
Harrell, CJP et al(2011) Multiple Pathways Linking Racism to Health Outcomes, Dubois Review: Social Sciences Research on Race- summarizes evidence pointing to psychophysiologcal pathways linking facets of racist environments to disease pathways.
Geronimus, A (2010) Do US Black Women Experience Accelerated Biological Aging? Human Nature: An Interdisciplinary Biological Perspective 21(1): 19-38