Jacqueline Dresch's Research

The study of gene regulation has been an important topic in biology for decades.  Accompanying the expansion in sequence data, new technologies have provided copious amounts of gene expression data suitable for modeling studies. To better understand the processes of gene regulation, mathematical models have been implemented that describe how DNA sequences direct differentiated gene expression, predict the expression of unknown genes or variants of genes, and reveal the driving forces behind gene regulation.  Prof. Dresch works in collaboration with the Drewell lab to use mathematical modeling to investigate the complex molecular machinery involved in regulating gene expression.  By implementing modeling approaches involving techniques from a wide range of areas, including data analysis, image processing, sensitivity analysis, model derivation, and parameter estimation, her research group focuses on phenomena such as the binding preference of a particular transcription factor, the cooperativity of multiple transcription factors, and the quenching efficiency of particular transcription factors on others.