Course Outline
Date | Topic | Reading | |
Introduction | |||
January 28 | Introduction to neuroscience | Chapter 1 | |
30 | SG | Approaches to studying brain and behavior | Chapter 2 |
February 1 | ST | Outline of neuroanatomy | Chapter 7 (168-180; 193-199; 205-235); Chapter 15 (490-497) |
Development of the nervous system | |||
4 | SG | Neurogenesis, migration | Chap. 7 (178-195); 23 (690-8) |
5 | Axon pathfinding; cell death | Chapter 23 (698-708) | |
8 | Role of neural activity in development Sheetz AJ, Williams RW, and Dubin MW Severity of ganglion cell death during early postnatal development is modulated by both neuronal activity and binocular competition. Visual Neuroscience 12 (1995) 605-610. | ||
Electrical signalling | |||
11 | Membranes and membrane potentials | Chapter 3 | |
13 | Action potential | Chapter 4 | |
15 | Conductance mechanisms Stringer JL. Regulation of extracellular potassium in the developing hippocampus. Developmental Brain Research 110 (1998) 97‑103. | ||
Synaptic transmission | |||
18 | Chemical and electrical transmission | Chapter 5 (102-122) | |
20 | Postsynaptic potentials; neural integration | Chapter 5 (122-131) | |
21/22 | Exam 1 | ||
25 | ST | Neurotransmitter systems | Chapter 6; Chapter 15 (498-507) |
27 | Castner SA, Xiao L, Becker JB. Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies. Brain Research 610 (1993) 127-134. | ||
29 | Morgan DG et al. Divergent changes in D-1 and D-2 dopamine binding sites in human brain during aging. Neurobiology of Aging 8 (1987) 95-201. | ||
Sensory Neuroscience | |||
March 3 | SG | Vision: transduction; receptive fields | Chapter 9 (288-306) |
5 | Visual information processing | Chapter 10 (310-329) | |
7 | Visual cortex Chapter 10 (324-348) Ferster D, Chung S, Wheat H. Orientation selectivity of thalamic input to simple cells of cat visual cortex. Nature. 380 (1996) 249‑52. | ||
10 | Visual plasticity; critical periods | Chapter 23 (708-716) | |
12 | Somatosensory system | Chapter 12 (388-408) | |
14 | Pain Chapter 12 (408-421) Eisenberger NI, Lieberman MD, Williams KD. Does rejection hurt? An FMRI study of social exclusion. Science. 302 (2003) 290‑292. | ||
[Spring break] | |||
24 | ST | Chemoreception Chapter 8 Curtis KS, Contreras RJ. Sex differences in electrophysiological and behavioral responses to NaCl taste. Behavioral Neuroscience 120 (2006) 917-924. | |
26 | Auditory system | Chapter 11 (344-375) | |
28 | Auditory system II Wu H.-C. et al. Influence of auditory deprivation upon the tonotopic organization in the inferior colliculus: a Fos immunocytochemical study in the rat. Eur. J. Neuroscience 17 (2003) 2540-2552 | ||
Sensorimotor control systems | |||
31 | Spinal mechanisms | Chapter 13 | |
April 2 | Brain mechanisms Chapter 14 Perese DA, Ulman J, Viola J, Ewing SE, Bankiewicz KS. A 6-hydroxy-dopamine-induced selective parkinsonian rat model. Brain Research 494 (1989) 285-293. | ||
3/4 | Exam 2 | ||
Neural basis of behavioral plasticity | |||
7 | SG | Human and animal memory | Chapter 24 |
9 | Cellular mechanisms of neural plasticity | Chapter 23 (716-722); Chap. 25 | |
11 | Clem RL, Tansu C, Barth AL Ongoing in vivo experience triggers synaptic metaplasticity in the neocortex. Science 319 (2008) 101-104. | ||
Neuroendocrine and motivational systems | |||
14 | ST | Endocrine systems | Chapter 15 (482-490);Chapter 17 |
16 | Bado C, Rissman EF. Androgen receptor is essential for sexual differentiation of responses to olfactory cues in mice. Eur. J. Neuroscience 25 (2007), 2182-2190. | ||
18 | JPB | Feeding behavior | Chapter 16 (510-527) |
21 | ST | Stress I | Chapter 18 (573-582); Ch 22 (668-670) |
23 | Stress II Yaka R et al. Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats. Behavioural Brain Res. 179 (2007) 126-132 | ||
24/25 | Exam 3 | ||
Diseases of the nervous system | |||
28 | Addiction Chap.16 (504-507; 522-527) Box 16.5 p. 526 Cruz FC, Marin MT, Planeta CS. The reinstatement of amphetamine-induced place preference is long-lasting and related to decreased expression of AMPA receptors in the nucleus accumbens. Neuroscience 151 (2008) 313-319 | ||
30 | Depression Chapter 22 (673-679) Hattori, S., et al. Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi. Behavioural Brain Res. 180 (2007) 69-76 | ||
May 2 | The Emerging Role of Bioenergetic Strategies in Treating Neurological Disorders: Huntingtons Disease Guest Lecture: Dr. Robert Ferrante Box 14.3 p. 468 | ||
5 | Schizophrenia Chapter 22 (679-685)
Flagstad P, Glenthoj BY, Didriksen M. Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia. Neuropsychopharmacology 30 (2005) 250-260. | ||
7 | SG | Alzheimer disease Box 2.3 p. 36-37
Verret L, Jankowsky JL, Xu GM, Borchelt DR, Rampon C. Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis. Journal of Neuroscience 27 (2007) 6771-80 | |
9 | Review /catchup session [+ Neuroscience Senior Thesis presentations] | ||
Final exam: 3-day take home, due during finals period |