Holda Anagho ’14 is a doctoral student in infection biology at Hannover Medical School in Germany, where she studies interactions between Hepatitis Delta Virus (HDV) and host cells in the lab of Professor Thomas von Hahn, M.D. At Amherst, she majored in biology, where she first became excited about research after a summer internship in Professor Caroline Goutte’s lab. While at Amherst, she also took several German language courses and served as president of the German theme house. After graduation, she spent a year as a research fellow at the National Cancer Institute in Bethesda, where she conducted research on the effects of immunomodulatory drugs in primary effusion lymphoma, caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) in the lab of Dr. Robert Yarchoan '71, M.D. There she first became interested in viruses. With generous support from Amherst College through the Kellogg Fellowship, she enrolled in the master's program in molecular biosciences at the University of Heidelberg in Germany, where she majored in infectious diseases. She did her master's thesis research in the lab of Dr. Pierre-Yves Lozach on entry and fusion of the Uukuniemi phlebovirus (UUKV) in mammalian cells. UUKV is an arthropod-borne virus closely related to emerging viruses that are highly pathogenic to humans, including Rift Valley fever virus, Heartland virus and Crimean-Congo hemorrhagic fever virus. UUKV, which is nonpathogenic to humans, is therefore used as a model system to study its more pathogenic counterparts.
UUKV is closely related to emerging pathogenic viruses in the Phenuiviridae family that cause severe and sometimes fatal disease in humans, animals and plants. To release its viral genome into a cell, Uukuniemi virus must fuse its viral membrane with the host cell membrane. Fusion of the UUKV membrane is mediated by the viral Glycoprotein C (GC), which is thought to be a class II fusion protein. We aimed to characterize mechanisms of UUKV fusion in mammalian cells. To this end, we analyzed the effect of low pH on virus binding and entry, conducted functional studies of UUKV GC mutants to analyze effects on viral fusion, and tested peptides corresponding to regions of the GC ectodomain for their ability to inhibit viral entry.
Come speak with one of over 30 program representatives at the study away fair! Programs and universities from the U.S. and around the world are eager to share their offerings with you. Over 45% of the junior class studies abroad each year – come learn what it’s all about! Whether you are interested in learning a language, conducting research or enrolling at a foreign university, the fair is an excellent point to begin research programs. Learn more about the event below.
Edward Slingerland is Distinguished University Scholar and Professor of Asian Studies at the University of British Columbia, with associate appointments in philosophy and psychology. His research specialties and teaching interests include early Chinese thought, religious studies, cognitive linguistics, ethics, and the relationship between the humanities and the natural sciences. His publications include several academic monographs and edited volumes and approximately 30 refereed articles in top journals in a wide variety of fields.
Many early Chinese thinkers had as their spiritual ideal the state of wu-wei, or effortless action. By advocating spontaneity as an explicit moral and religious goal, they inevitably involved themselves in the paradox of wu-wei—the problem of how one can try not to try—which later became one of the central tensions in East Asian religious thought. In this talk, Slingerland will look at the paradox from both an early Chinese and a contemporary perspective, drawing upon work in economics, social psychology, cognitive neuroscience and evolutionary theory to argue that this paradox is a real one, and is moreover intimately tied up with cooperation dilemmas in large-scale societies and concerns about trust and moral hypocrisy.
The public is welcome. Refreshments and meet-and-greet will follow the lecture.
Come to the common room in Charles Pratt Hall (next to the Writing Center) on Monday September 17 at 5:30 p.m. to learn more about being involved with Amherst College's new online multilingual magazine: Confluences: Lost & Found in Translation. There are opportunities for writing, editing, translating, website management and helping to shape the future of this ongoing project.
For more than 25 years, Cornerstone Research has provided economic and financial analysis in all phases of commercial litigation and regulatory proceedings. The firm works with a broad network of testifying experts, including prominent faculty and industry practitioners, in a distinctive collaboration. Staff consultants contribute expertise in economics, finance, accounting and marketing, as well as business acumen, familiarity with the litigation process, and a commitment to produce outstanding results.
Cornerstone Research has 700 staff, and offices in Boston, Chicago, London, Los Angeles, New York, San Francisco, Silicon Valley and Washington. The company aims to recruit and retain outstanding individuals who have built Cornerstone Research into a highly respected firm with strong core values and a collegial culture.
Recruiters look for exceptional graduates who are team-oriented leaders, passionate about solving complex business problems, and excited about contributing to the growth of the firm. Attend this information session to find out more!
The Writing Center's Creative Writing Group will gather weekly on Monday nights to write, share and discuss our fiction, creative non-fiction, poetry, drama and other modes of creative writing in a friendly, supportive manner. No homework, just attend. Meetings will be led by writing associate Roy Andrews and student coordinator Gwyneth Lewis. Open to all students.
The Data Science Development Program (DSDP) trains promising, recent graduates to become well-rounded data scientists at MassMutual over three years. Participation in the development program includes mentorship from senior data scientists, exposure to real world, high-impact data science projects, in-house training and workshops, and tuition sponsorship for graduate-level classes at UMass Amherst.
Junior Data Scientists in the DSDP are fully immersed in high-impact data science projects for MassMutual under the direction of a senior data scientist. Junior data scientists work together with MassMutual’s data scientists to solve challenging problems in fields such as finance, operations, marketing, digital initiatives, and product development. Data science projects typically involve statistical data analysis, predictive analytics, modeling and machine learning, as well as developing web-based interactive visualization tools.
Each member of the program completes a blended curriculum of Five College coursework, in-house workshops led by local faculty, online courses, and graduate-level study. The coursework is customized to address individual interests and guided by advisors. Typical coursework encompasses upper-level computer science classes, such as machine learning, graphical models, natural language processing, and databases, and upper-level statistics classes, such as mathematical statistics, applied regression, multivariate analysis, and applied experimental design.
Attend this information session to hear more from program director Christine Pfeil about DSDP’s coursework, application processes, and overall benefits.