Event Calendar

Friday, March 29, 2019

Fri, Mar 29, 2019

Headshot of Kendra Frederick

Chemistry Seminar with Professor Kendra Frederick: "In-Cell Structural Biology of Proteins Behaving Badly"

Professor Kendra Frederick of the University of Texas Southwestern Medical School Biophysics Department, an NIH New Innovator Awardee, will give a seminar titled "In-Cell Structural Biology of Proteins Behaving Badly."

Brief Abstract: The misfolded proteins associated with neurodegenerative disease can adopt a variety of different conformations, some of which are toxic. Because these proteins have identical amino acid sequences, the cellular environment clearly influences the final state, yet most structural studies do not include the cellular context, and, perhaps because we are not studying the correct conformation, not a single therapeutic strategy for these diseases addresses the underlying protein-misfolding pathology. Using new sensitivity-enhancement technology for solid-state NMR spectroscopy, we study protein structure in native environments-- inside living cells --to reveal how both healthy and disease-relevant cellular environments influence protein structure.