Torsten Klengel, M.D., Ph.D., assistant professor of psychiatry at Harvard Medical School and director of the Translational Molecular Genomics Laboratory at McLean Hospital, will speak on “Translational Research in Psychiatry from Humans to Monkeys and Back.”
Abstract: Genetic and environmental factors profoundly influence the risk to develop psychiatric disorders. A number of large clinical studies provide evidence for the long-term effects of early life stress on disease trajectories across the lifespan and even across generations. My talk will focus on the concept of gene-environment interaction and how the environment influences epigenetic cellular programming with a focus on HPA axis function. I will introduce the concept of inter- and transgenerational effects of environmental exposure and how nonhuman primate studies can bridge a translational gap between studies in rodents and clinical studies in humans.
Refreshments will be served.