Kamilah Ali, Ph.D.
Assistant Professor, Basic Science
Course Director, Pharmacology
Touro College of Osteopathic Medicine
Title: “The Forgotten One: ApoD, Lipoprotein Oxidation and Atherosclerosis”
Coronary artery disease (CAD) is one of the leading causes of death in the United States. The pathogenesis of CAD is complex and is due to the development of plaque, the accumulation of cholesterol in macrophages, in blood vessels that can cause thrombosis, leading to a heart attack or stroke. Some of the key players or steps in accumulation of cholesterol are the levels of plasma lipoproteins, oxidative capacity of LDL-cholesterol, and the inflammatory state of macrophages. Apolipoproteins (apos) are major determinants in regulating human plasma lipoprotein levels, thus affecting plaque formation (atherogenesis) in blood vessels. Our protein of interest, ApoD, is associated with plasma high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very low-density lipoproteins (VLDL), and is ubiquitously expressed in tissues and present in cell types (endothelial cells (EC), vascular smooth muscle cells (VSMC), macrophages) involved in plaque formation. However, we have a poor understanding of the role(s) and mechanism(s) of apoD in plaque development. We use in vivo animal models on a Western diet, lipid biochemistry and cell culture to address our hypothesis. Our preliminary data suggest that apoD is anti-atherogenic whose effects may be mediated by modulating LDL oxidation and/or downstream activation of macrophage- vascular smooth muscle cells signaling pathways.
This talk examines how Black Caribbean youth perceive and experience the state-endorsed "Stop and Search" program in London and then-ongoing "Stop and Frisk" practices in New York City while on route to and from public schools between 2007 and 2014. Despite a growing body of scholarship on the relationship between policing and schooling in the U.S. and U.K., comparative research on how school students experience stop-and-frisk/search practices remains sparse. Drawing on the BlackCrit tradition of Critical Race Theory and in-depth interviews with 60 Black Caribbean secondary school students, this article explores how adolescents experience adultlike policing to and from schools. The findings indicate that participants develop a strained sense of belonging in British and American societies due to a security paradox—a policing formula that promises safety for all in principle, but does so at the expense of some Black youth in practice. Participants learned that, irrespective of ethnicity, Black youth are regularly rendered suspicious subjects worthy of scrutiny, even during the school commute. This paper concludes with recommendations that can assist in improving students’ safety while en route to and from school.
Derron Wallace is an assistant professor of education and sociology at Brandeis University, with joint affiliations in African and Afro-American studies and social justice and social policy. He is a sociologist of race, ethnicity and education who specializes in cross-national studies of inequalities and identities in urban schools and neighborhoods, focusing specifically on the experiences of young people of African descent. His work has appeared in journals such as Sociology: The Journal of the British Sociological Association, The British Journal of Sociology of Education and Harvard Educational Review. His research has been supported by the Andrew W. Mellon Foundation, the Gates Cambridge Trust, the Marion & Jasper Whiting Foundation and the Hutchins Center for African and African American Research. Prior to joining the Brandeis faculty, he served as a professional community organizer in London, working on youth safety, living wages, fair housing and immigrant rights campaigns.