Selected Publications

Notes: Asterisk (*) indicates Amherst College undergraduate co-author. Publications are peer-reviewed original-research articles unless otherwise noted.

Chio CM,* Cheng KW* & Bishop AC. Direct chemical activation of a rationally engineered signaling enzyme. ChemBioChem doi: 10.1002/cbic.201500245. [Epub ahead of print] (2015).

Chio CM,* Yu X* & Bishop AC. Rational design of allosteric-inhibition sites in classical protein tyrosine phosphatases. Bioorganic & Medicinal Chemistry 23, 2828-2838 (2015).

Pomorski A, Adamczyk J, Bishop AC & Krężel A. Probing the target-specific inhibition of sensitized protein tyrosine phosphatases with biarsenical probes. Organic & Biomolecular Chemistry 13, 1395-1403 (2015).

Chio CM,* Lim CS* & Bishop AC. Targeting a cryptic allosteric site for selective inhibition of the oncogenic protein tyrosine phosphatase Shp2. Biochemistry 54, 497-504 (2015).

Harris LK,* Frumm SM* & Bishop AC.  A general assay for monitoring the activities of protein tyrosine phosphatases in living eukaryotic cells. Analytical Biochemistry 435, 99-105 (2013).

Davis OB* & Bishop AC.  Inhibition of sensitized protein tyrosine phosphatase 1B (PTP1B) with a biarsenical probe. Bioconjugate Chemistry 23, 272-278 (2012).

Walton ZE* & Bishop AC.  Target-specific control of lymphoid-specific protein tyrosine phosphatase (Lyp) activity. Bioorganic & Medicinal Chemistry 18, 4884-4891 (2010).

Chen VL* & Bishop AC.  Chemical rescue of protein tyrosine phosphatase activity. Chemical Communications 46, 637-639 (2010).

 Bishop AC & Chen VL.* Brought to life: Targeted activation of enzyme function with small molecules. Journal of Chemical Biology (Invited Review) 2, 1-9 (2009).

 Zhang XY, Chen VL,* Rosen MS,* Blair ER,* Lone AM* & Bishop AC. Allele-specific inhibition of divergent protein tyrosine phosphatases with a single small molecule. Bioorganic & Medicinal Chemistry 16, 8090-8097 (2008).

 Zhang XY & Bishop AC. Engineered inhibitor sensitivity in the WPD loop of a protein tyrosine phosphatase. Biochemistry 47, 4491-4500 (2008).

 Zhang XY & Bishop AC. Site-specific incorporation of allosteric-inhibition sites in a protein tyrosine phosphatase. Journal of the American Chemical Society 129, 3812-3813 (2007).

 Bishop AC, Zhang XY & Lone AM.* Generation of inhibitor-sensitive protein tyrosine phosphatases via active-site mutations. Methods (Invited Article) 42, 278-288 (2007).

 Savage DF,* de Crécy-Lagard V & Bishop AC. Molecular determinants of dihydrouridine synthase activity. FEBS Letters 580, 5198-5202 (2006).

Bishop AC & Blair ER.* A gatekeeper residue for inhibitor sensitization of protein tyrosine phosphatases. Bioorganic & Medicinal Chemistry Letters 16, 4002-4006 (2006).

 Blair ER,* Hoffman HE* & Bishop AC. Engineering non-natural inhibitor sensitivity in protein tyrosine phosphatase H1. Bioorganic & Medicinal Chemistry 14, 464-471 (2006).

 Hoffman HE,* Blair ER,* Johndrow JE* & Bishop AC. Allele-specific inhibitors of protein tyrosine phosphatases. Journal of the American Chemical Society 127, 2824-2825 (2005).

 Bishop AC, Xu J, Johnson RC, Schimmel P & de Crécy-Lagard V. Identification of the tRNA-Dihydrouridine Synthase Family. Journal of Biological Chemistry 277, 25090-25095 (2002).

 Bishop AC, Nomanbhoy TK & Schimmel P. Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America 99, 585-590 (2002).

 Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, Blethrow J, Shimizu E, Tsien JZ, Schultz PG, Rose MD, Wood JL, Morgan DO & Shokat KM. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401 (2000).

 Bishop AC, Kung C-Y, Shah K, Witucki L, Shokat KM & Liu Y. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. Journal of the American Chemical Society 121, 627-631 (1999).

 Bishop AC, Shah K, Liu Y, Witucki L, Kung C-Y & Shokat KM. Design of allele-specific inhibitors to probe protein kinase signaling. Current Biology 8, 257-266 (1998).