427 McGuire Life Sciences Building
PO Box: AC# 2237
413-542-8321
Please call the college operator at 413-542-2000 or e-mail info@amherst.edu if you require contact info@amherst.edu

Caroline E. Goutte

Professor of Biology

Departmental affiliations:Biochemistry-Biophysics; Biology; Neuroscience

Interests

Molecular mechanisms of cell and developmental biology, genetic analysis of model systems, Notch signaling pathway in C. elegans

Professional and Biographical Informations

Degrees

Ph.D., University of California, San Francisco, Biochemistry (1992)
B.A., Cornell University, Biology (1985)

Post Doctoral Fellow

Fred Hutchinson Cancer Research Center, Seattle, WA (1992-1996)

Teaching Interests

I am fortunate to be able to teach what I am most passionate about: genetics. In the introductory biology course, Molecules, Genes, and Cells (Biology 191) I aim to bring students a solid picture of the fundamental concepts of molecular and classical genetics, equipping them with enough detail to inspire them to question further and push the limits of their own curiosity and understanding. In Genetic Analysis of Biological Processes (Biology 241) I spend the entire semester dragging students down with me into the trenches of genetic research and the process of scientific discovery. In this course my aim is to teach students how genetic analysis is used to tackle fundamental questions in biology, and I do this by guiding them through an intimate semester-long genetic quest to understand the yeast mating process. I have also taught the introductory course Chemical Basis of Biological Processes, Developmental Biology, Seminar in Developmental Genetics, and first-year seminars Gender and Science as well as Genes, Genomes, and Society.

Selected Publications

Hale, Valerie A., Guiney, Evan L. ['06], Goldberg, Lindsey Y. ['05], Haduong, Josie H. ['99], Kwartler, Callie S. [07], Scangos, Katherine W. ['02], and Goutte, Caroline.  (2012). Notch Signaling is Antagonized by SAO-1, a Novel GYF-Domain Protein That Interacts with the E3 Ubiquitin Ligase SEL-10 in Caenorhabditis elegansGenetics. 2012 Mar;190(3):1043-57. Epub 2011 Dec 29.

Goutte, Caroline, Tsunozaki, Makoto ['00], Hale, Valerie A. and Priess, James R. (2002). APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proceedings of the National Academy of Sciences USA 99:775-779.

Goutte, C. (2002). Genetics leads the way to the accomplices of presenilins. Developmental Cell 3:6-7.

Levitan, Diane, Yu, Gang, Hyslop, Peter St. George, and Goutte, Caroline (2001). APH-2/Nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad. Developmental Biology 240:654-661.

Goutte, Caroline, Hepler, William, Mickey, Katherine M. and Priess, James R. (2000). Aph-2 encodes a novel extracellular protein required for GLP-1 mediated signaling. Development 127:2481-2492.

Awards and Honors

National Science Foundation Award (2002-2006). Program in Developmental Mechanisms, “The Role of APH-1 and APH-2 in Notch-Mediated Cell Interactions in C. elegans"

National Science Foundation Award (1998-2002). Program in Developmental Mechanisms, “New Components of Notch-Mediated Cell-Cell Interactions in C. elegans”

Trustee Faculty Fellowship Award, Amherst College (fall 1999–spring 2000). "A Genetic Search for Molecules that Mediate Cell Communication"

Life Sciences Research Foundation Postdoctoral Fellowship (1992-1995)

Scholarly and Professional Activities

Postdoctoral Fellow, Fred Hutchinson Cancer Research Center, Seattle, WA (1992-1996)

Co-organizer of Teaching Workshops, International C. elegans Meetings, UCLA, CA. (2001-present)

Ad hoc reviewer for Developmental Biology, Proceedings of the National Academy of Sciences, and Genetics, and for the National Science Foundation's Program in Developmental Mechanism and Program in Evolution of Developmental Mechanisms

 

See also: Research Interests and Selected Publications