Ph. D., Dartmouth College (2008)
M. S., Pohang University of Science and Technology (2002)
B. E., Yonsei University (2000)
Professional Training and Experience
Assistant Scientist, University of Wisconsin-Madison (2014-2015)
Howard Hughes Medical Institute Teaching Fellow, University of Wisconsin-Madison (2013)
Postdoctoral Fellow, University of Wisconsin-Madison (2009-2014)
I teach Molecular Genetics, Biochemistry, and an advanced seminar, Biology of Metals.
Molecular Genetics explores the structure, function, regulation, and interaction of genes at a molecular level. Biochemistry deals with the chemical processes that relate to life, including the structure, function, and interaction of molecules; flow of energy; and metabolic pathways that occur in a cell or a living organism. Molecular Genetics and Biochemistry are closely related subfields of molecular biology highly relevant to my own area of research.
My seminar focuses on the molecular and cellular biology of metals. Topics of discussion include metal homeostasis strategies, role of metals in biochemical processes, inherited metal metabolism disorders, and genetics of hyperaccumulators. We also discuss prospects of manipulating metal homeostasis to aid human health and environmental sustainability.
Metals such as iron, zinc, or copper, are micronutrients required for vital cellular processes. Paradoxically, these metals are potentially toxic due to the chemical properties that make them useful. Therefore, organisms have evolved delicate strategies to tightly maintain homeostasis of metals. Research in my laboratory focuses on unraveling the molecular mechanisms that regulate iron homeostasis in plants, using the model plant Arabidopsis thaliana and yeast Saccharomyces cerevisiae. We are interested in understanding the molecular players involved in iron transport at the cellular and organellar level.
Studying iron homeostasis in plants will not only offer the joy of basic scientific research, but could impact human nutrition. According to the World Health Organization, iron deficiency in the most common nutritional disorder worldwide and the only nutrient deficiency prevalent in industrialized countries. Given that plants are the primary dietary source of iron worldwide, understanding plant iron homeostasis is pivotal for improving human nutrition. We expect to gain insights for biofortification, which is necessary to provide a sustainable solution to malnutrition worldwide.
Amherst College student co-authors are denoted by *.
Jeong J, Merkovich A '17*, Clyne M '18*, Connolly EL. (2017) Directing iron transport in dicots: regulation of iron aquisition and translocation. Curr. Opin. Plant Biol. 39:106-113.
MacDiarmid CM, Taggart J, Jeong J, Kerdsomboon K, Eide DJ. (2016) Activation of the yeast UBI4 polyubiquitin gene by Zap1 via an intragenic promoter is critical for zinc-deficient growth. J. Biol. Chem. 291:18880-96.
Jeong J, Eide DJ. (2013) SLC39 family of metal ion transporters. Mol. Asp. Med. 34:612-619.
Jeong J, Walker J, Wang F, Park JG, Palmer AE, Rorhbach M, Giunta C, Steinmann B, Eide DJ. (2012) Promotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome. Proc. Natl. Acad. Sci.109: E3530-E3538. [Recommended by Faculty1000. http://f1000.com/prime/717969071].
Jeong J, Guerinot ML. (2009) Homing in on iron homeostasis in plants. Trends Plant Sci. 14:280-285.
Jeong J, Connolly EL. (2009) Iron uptake mechanisms in plants: functions of the FRO family of ferric reductases: Plant Sci. 176:709-714.
Jeong J, Guerinot ML. (2008) Biofortified and bioavailable: The golden standard for plant-based diets. Proc. Natl. Acad. Sci.105:1777-1778.
Jeong J, Cohu C, Kerkeb L, Pilon M, Connolly EL, Guerinot ML. (2008) Chloroplast Fe(III) chelate reductase activity is essential for seedling viability under iron limiting conditions. Proc. Natl. Acad. Sci. 152:2301-2308.
Jeong J, Suh S, Guan C, Tsay YF, Moran N, Oh CJ, An CS, Demchenko KN, Pawlowski K, Lee Y. (2004) A nodule-specific dicarboxylate transporter from alder is a member of the peptide transporter family. Plant Physiol. 134:969-78.
Lee J, Bae H, Jeong J, Lee JY, Yang YY, Hwang I, Martinoia E, Lee Y. (2004) Functional expression of a bacterial heavy metal transporter in Arabidopsis enhances resistance to and decreases uptake of heavy metals. Plant Physiol. 133:589-96. [Recommended by Faculty1000. http://f1000.com/prime/1003741#cite]