Ph.D., Dartmouth College (2009)
Molecular Genetics with Lab (BIOL 371)
Epigenetics (BIOL 376)
Molecules, Genes, and Cells (BIOL 191)
The goal of the Lee laboratory is to understand the epigenetic regulation of chromatin switches in response to environmental cues, using a well-established, cold-induced epigenetic switch in plants. Plants are an excellent model for epigenetic research because epigenetic mutants are typically viable and heritable, whereas mammalian epigenetic mutations are often lethal and difficult to study in the whole organism. In addition, the well-studied vernalization system, a temperature-sensing process by which exposure to prolonged cold during winter leads to an epigenetic switch that permits flowering in the spring, provides a controllable experimental model for epigenetic studies. Cold memory is a mitotically-maintained epigenetic switch that promotes flowering in spring. Our efforts expect to understanding epigenetic mechanisms that occur the upstream of Polycomb Repressive Complex 2 (PRC2) -mediated gene silencing, which is highly conserved among eukaryotes.
Schwartz CJ, Lee J, Amasino R. Variation in shade-induced flowering in Arabidopsis thaliana results from FLOWERING LOCUS T allelic variation. PLoS One. 2017 12(11):e0187768.
Woods DP, Ream TS, Bouché F, Lee J, Thrower N, Wilkerson C, Amasino RM. Establishment of a vernalization requirement in Brachypodium distachyon requires REPRESSOR OF VERNALIZATION1. Proceedings of the National Academy of Science. 2017 114(25):6623-6628.
Lee J, Yun JY, Zhao W, Shen WH, Amasino RM. A methyltransferase required for proper timing of the vernalization response in Arabidopsis. Proceedings of the National Academy of Science. 2015 112(7):2269-74.
Lee J, Amasino RM. Two FLX family members are non-redundantly required to establish the vernalization requirement in Arabidopsis. Nature Communications. 2013;4:2186.
Lee S, Jeong HJ, Kim SA, Lee J, Guerinot ML, An G. OsZIP5 is a plasma membrane zinc transporter in rice. Plant Molecular Biology. 2010 73(4-5):507-17
Lee S, Kim SA, Lee J, Guerinot ML, An G. Zinc deficiency-inducible OsZIP8 endoces a plasma membrane-localized zinc transporter in rice. Molecules and Cells. 2010 29(6):551-8
Shim D, Hwang JU, Lee J, Lee S, Choi Y, An G, Martinoia E, Lee Y. Orthologs of the class A4 heat shock transcription factor HsfA4a confer cadmium tolerance in wheat and rice. Plant Cell. 2009 21(12):4031-43
Morrissey J, Baxter IR, Lee J, Li L, Lahner B, Grotz N, Kaplan J, Salt DE, Guerinot ML. The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis. Plant Cell. 2009 21(10):3326-38.
Baxter I, Muthukumar B, Park HC, Buchner P, Lahner B, Danku J, Zhao K, Lee J, Hawkesford MJ, Guerinot ML, Salt DE. Variation in molybdenum content across broadly distributed populations of Arabidopsis thaliana is controlled by a mitochondrial molybdenum transporter (MOT1). PLoS Genetics. 2008 4(2):e1000004.
Kim YY, Kim DY, Shim D, Song WY, Lee J, Schroeder JI, Kim S, Moran N, Lee Y. Expression of wheat TM20 confers enhanced cadmium tolerance to baker’s yeast. The Journal of Biological Chemistry, 2008 283(23):15893-902
Lee M, Lee K, Lee J, Noh EW, Lee Y. AtPDR12 contributes to lead resistance in Arabidopsis. Plant Physiology, 2005 Jun;138(2):827-36.
Lee J, Shim D, Song WY, Hwang I, Lee Y. Arabidopsis metallothioneins 2a and 3 enhance resistance to cadmium when expressed in Vicia faba guard cells. Plant Molecular Biology. 2004, 54(6):805-15.
Song WY, Martinoia E, Lee J, Kim D, Kim DY, Vogt E, Shim D, Choi KS, Hwang I, Lee Y. A novel family of cys-rich membrane proteins mediates cadmium resistance in Arabidopsis. Plant Physiology, 2004, 135(2):1027-39
Lee J, Bae H, Jeong J, Lee JY, Yang YY, Hwang I, Martinoia E, Lee Y. Functional expression of a bacterial heavy metal transporter in Arabidopsis enhances resistance to and decreases uptake of heavy metals. Plant Physiology, 2003, 133(2):589-96