Merrill Science
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Keisuke Hasegawa

Visiting Assistant Professor of Physics

Departmental affiliations: Biochemistry-Biophysics; Physics and Astronomy

Submitted by Keisuke Hasegawa on Sunday, 6/29/2014, at 10:04 PM

Professional Information

Positions

Visiting Assistant Professor, Amherst College, January 2014-Present.
Co-instructor, University of Maryland, College Park, September-December 2013.
Postdoctoral Visiting Fellow, National Cancer Institute, NIH, 2009-2013.

Degrees

Ph.D., University of Oregon, 2008.
B.A., Reed College, 2001.

Research Interests

The primary focus of my lab is to examine biophysical processes that govern the self-assembly of the mitotic spindle, a macromolecular machine that segregates chromosomes in a dividing cell, using optical microscopy and computational modeling. Investigations into the biophysics of mitotic spindle assembly would help us understand how proteins, DNA, and other biomolecules self-organize themselves into living, self-replicating cells. Such investigations may also lead to a new cancer therapy since a disruption of the mitotic spindle assembly is an effective way to treat cancer.

 

Selected Publications

  • K. Hasegawa, S.J. Ryu, and P. Kalab, "Chromosomal gain promotes formation of a steep RanGTP gradient that drives mitosis in aneuploid cells," Journal of Cell Biology 200, 151-161 (2013).
  • N.A. Kuhta, A. Chen, K. Hasegawa, M. Deutsch, and V.A. Podolskiy, "Asymmetric reflectance and cluster size effects in silver percolation films," Physical Review B 84, 165130 (2011).
  • J.F. Soderholm, S. Bird, P. Kalab, Y. Sampathkumar, K. Hasegawa, M. Uehara-Bingen, K. Weis, and R. Heald, "Importazole, a small molecule inhibitor of the transport receptor importin-β," ACS Chemical Biology 6, 700-708 (2011).
  • K. Hasegawa, J. U. Nöckel, and M. Deutsch, "Curvature-induced radiation of surface plasmon polaritons propagating around bends," Physical Review A 75, 063816 (2007).
  • K. Hasegawa, C. Rohde, and M. Deutsch, "Enhanced surface-plasmon resonance absorption in metal-dielectric-metal layered microspheres," Optics Letters 31, 1136-1138 (2006).
  • C.A. Rohde, K. Hasegawa, and M. Deutsch, "Coherent light scattering from semicontinuous silver nanoshells near the percolation threshold," Physical Review Letters 96, 045503 (2006).
  • K. Hasegawa, J. U. Nöckel, and M. Deutsch, "Surface plasmon polariton propagation around bends at a metal-dielectric interface," Applies Physics Letters 84, 1835 (2004).
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