Professional and Biographical Information

Degrees

B.A. Chemistry University of Kansas (1957)
Ph.D. Chemistry University of California at Berkeley (1961)

Positions

Thomas B. Walton Jr. Memorial Professor of Biology, emeritus (Amherst College)
Adjunct Professor Veterinary & Animal Science (The University of Massachusetts at Amherst)
Visiting Scientist (The Whitehead Institute)

Professional Profile

Academic appointments have included: Faculty and administrative appointments at Yale, The University of Maryland at College Park, The University of Massachusetts at Amherst and Amherst College as well as a visiting faculty appointment at Stanford University.  More than 30 years of a  long career have been spent enjoying the privilege of teaching undergraduates at Amherst College.  I have had the opportunity to teach Immunology, The Cellular and Molecular Biology of Cancer to generations of students in the Biology and Chemistry Departments.  Teaching Cancer & AIDS: the Biology of Catastrophe has provided an opportunity to explore the important interfae between biology and human affairs with the larger community of Amherst students whose major interests lie outside the sciences.

Professional Positions in the chemical or biotechnology industry have included: Employment as staff scientist at Monsanto and at Dupont; Co-Founder of Hematech and service as Head of its Scientific Advisory Board; Consultantships at Bayer and Vicam; Member Immunogenes Advisory Board.

Professional Service includes: NIH Study Section for Allergy & Clinical Immunology (4 years); NIH Board of Scientific Counselors for the National Institute of Allergy & Infectious Disease (4 years); Course Director for the NSF-Chautauqua Short Course for College Teachers (6 years); Member of the Visiting Committee for the Harvard School of Public Health (3 years).

Grants and Honors

  • Numerous federal grants including awards from NASA, USDA, NSF and NIH RO1 & R15 grants
  • Several private sector grants including funding from Dupont, Bayer, Schering, Hematech and Vicam
  • Named Chairs at Amherst College (Walton Chair and Cross Chair)
  • Distinguished University Professor University of Massachusetts at Amherst
  • National Research Council Senior Associateship
  • American Society of Cell Biology Just Lectureship
  • American Association of Immunologists Vanguard Lectureship
  • Phi Beta Kappa

Bibliography

Books

Cells and Energy, (1rst ed., 1967; 2nd ed., 1977) Macmillan
Race and Races, (1rst ed., 1971; 2nd ed., 1977) Macmillan
Thinking AIDS [with Mary Catherine Bateson) 1989,  Addison Wesley
Kuby Immunology 4th edition (with T.J. Kindt & B.A. Osborne) 2000, W.H. Freeman
Immunology 5th edition (with T.J. Kindt & B.A. Osborne) 2003, W.H. Freeman
Kuby Immunology 6th edition (with T.J. Kindt & B.A. Osborne), 2007
Case Studies in Cancer (with R.J. B. Lee & J. Abramson) 2018, GarlandScience/Norton
Thinking Race (with Mary Catherine Bateson) in press 2019, Rowman & Littlefield

Selected Publications (from a list of 75)

Hoffman, C.E., Neumayer, E.M., Haff, R.F., and Goldsby, R.A. 1965.  Mode of action of the antiviral activity of amantadine in tissue culture.  J. Bacteriology 96:623.

Goldsby, R.A. and Zipser, E.  1969.  The isolation and replica plating of mammalian cell clones.  Experimental Cell Research 54:271.

Goldsby, R.A., Osborne, B.A., Simpson, E., Herzenberg, L.A.  1977.  Hybrid cell lines with T cell characteristics. Nature, 267: 707.

Goldsby RA, Osborne BA, Suri D, Mandel A, Williams J, Gronowicz E, Herzenberg LA, 1978.

Production of specific antibody without specific immunization.  Curr Top Microbiol Immunol. 81:149-51.

Engleman, E.G., Benike, C., Osborne, B.A., Goldsby, R.A.  1980.  Functional characteristics of human T cell subpopulations distinguished by a monoclonal antibody.  Proc. Natl. Acad.Sci., 77:1607.

Remmers, E.F., Colwell R.R., Goldsby, R.A.  1982.  Production and characterization of monoclonal antibodies to cholera toxin.   Infection and Immunity, 37: 70.

Srikumaran, S., Guidry, A.J., Goldsby, R.A.  1983.  Bovine x mouse hybridomas that secrete bovine immunoglobulin G1.   Science, 220: 522.

Lin, W.C., Goldsby, R.A. and Snoeyenbos, G.H. 1992.  Salmonella enteritidis-specific monoclonal antibodies.  Avian Diseases 36:455.

Ravichandran, K.S., Osborne, B.A. and Goldsby, R.A.  1994.  Quantitative analysis of the B cell repertoire by limiting dilution analysis and fluorescent in situ hybridization.  Cellular Immunology 154:309.

McLaughlin K. A, Osborne B. A. and Goldsby R. A.  1996.  Oxygen-dependent thymocyte deaths: Their demonstration and possible implications for thymic selection.  Eur. Journal of  Immunology: 26:1170.

Zheng, Biao, Han, S., Shou, Q, Goldsby, R. A. and Kelsoe, G.  1996.  Distinct pathways for selection of antigen-specific T cells in the peiphery.  Nature: 384:263.

Lucier, M.R., Thompson, R.E., Waire, J., Lin, A.W., Osborne, B.A., and Goldsby, R.A.  1998.  Multiple sites of V diversification in cattle.  Jounnal of Immunology:161:5438.

Jeong Y., Osborne. B.A., and Goldsby, R.A.  2001.  Early B Lambda diversification in sheep.  Immunology 103:26.

Kuroiwa Y., Kasinathan P., Choi Y.J., Naeem R., Tomizuka K., Sullivan E.J., Knott J.G., Duteau A., Goldsby R.A., Osborne B.A., Ishida I., Robl J.M.  2002.  Cloned transchromosomic calves producing human  immunoglobulin.  Nat Biotechnol. 20:889.

Dessain, S.K.,  Adekar, S.P. , Stevens J.B., Carpenter, K.A. , Skorski M., Barnoski B.,  Goldsby, R.A., and Weinberg, R.A. (2004).  High efficiency creation of human monoclonal antibody-producing hybridomas.  J. Immunol. Methods 291:109.

Kacskovics, I., Kis, Z., Mayer, B., West, A.P., Tiangco, N.E., Tilahun, M., Cervenak, L., Bjorkman, P.J., Goldsby, R.A., Scenci, O., Hammarstrom, L.  2006.  FcRn mediates elongated serum half-life of human IgG in Cattle.  International Immunology: 18:525.

Tilahun, M. E., G. Rajagopalan, N. Shah-Mahoney, R. G. Lawlor, A. Y.Tilahun, C. Xie, K. Natarajan, D. H. Margulies, D. I. Ratner, B. A. Osborne, and R. A. Goldsby. 2010. Potent Neutralization of SEB by Synergistic Action of Chimeric Antibodies. Infect. Immun. 78:2801

Mulualem E. Tilahun, Alan Kwan, Kannan Natarajan, Megan Quinn, Ashenafi Y.Tilahun, Chen Xie, David H. Margulies,  Barbara A. Osborne, Richard A. Goldsby and Govindarajan Rajagopalan  (2011)  Chimeric Anti-Staphylococcal Enterotoxin B Antibodies and Lovastatin Act Synergistically to Provide In Vivo Protection Against Lethal Doses of SEB.  PLoS One. 2011;6(11):e27203. Epub 2011 Nov 15.


American Association of Immunologists History Project

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May 13, 2017

The following interview is part of the American Association of Immunologists' History Project, conducted on May 13, 2017.